N atural gas (NG) is the cleanest fossil fuel. It is the bridging fuel of choice and the fastest growing energy source globally, as the world transitions from fossil fuels to renewables in the coming decades. The 2018 Outlook for Energy (ExxonMobil, 2018) projects the NG demand to increase by 40% from 2016 to 2040, as NG gradually displaces coal as the preferred fuel for power generation around the world. The liquefied form of NGnamely, LNGis the most economical means for transporting NG over long distances, as necessitated by the limited sources of NG. LNG is the fastest growing gas supply source (Shell LNG Outlook, 2018) with global demand expected to increase 4% annually (versus 1% for energy and 2% for NG) from 2017 to 2035. The abundant resources of and exciting prospects for NG/LNG along with the urgent need to mitigate carbon dioxide emissions are prompting researchers around the world to address a host of issues related to the NG value chain. This special issue provides a timely focus to some efforts that employ process systems engineering (PSE) approaches.NG recovered from a hydrocarbon field is typically transported via pipelines to a plant for pretreatment and/or upgrading to pipeline specifications. If the demand is local, then distribution grids supply the gas to the end consumers such as residences, power plants, and industries. If the demand is regional, then high-pressure transmission lines send the gas (piped natural gas (PNG)) to distant distribution grids. However, if the demand centers are global and far away, then marine transport as LNG is more economical than land transmission as PNG. In this case, the plant hosts an energyintensive liquefaction facility to produce the high-energydensity LNG and an export (loading) terminal to store it in atmospheric storage tanks at approximately −160 °C. LNG tankers then carry LNG in large heavily insulated specialized cargo tanks to import (receiving) terminals around the globe. An import terminal unloads and stores the LNG cargos into atmospheric storage tanks, and regasifies LNG continuously to send out NG at elevated pressures to local distribution grids. NG from the distribution grids is normally used for power generation or heating, but it can also be a feedstock for producing chemicals and petrochemicals. In summary, the NG value chain comprises steps such as recovery,