Design and optimization of process parameters of polyvinyl (alcohol)/chitosan/nano zinc oxide hydrogels as wound healing materials

Khorasani, Mohammad Taghi; Joorabloo, Alireza; Adeli, Hassan; Mansoori-Moghadam, Zohreh; Moghaddam, Armaghan

doi:10.1016/j.carbpol.2018.12.021

Cited by 168 publications

(53 citation statements)

References 43 publications

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“…The mechanical properties of chitosan-based wound dressings are also sometimes the focus of derivatizations utilizing crosslinking. Despite the unsuitability of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) hydrogels themselves as wound-dressing materials due to their insufficient elasticity and limited hydrophilicity [122], they are popular crosslinkers for chitosan-based hydrogels, to improve their tensile properties [123][124][125][126]. Crosslinking with genipin, a chemical compound found in gardenia fruit extract, is also popular [3,127].…”

Section: Derivatization Of Chitin and Chitosan To Improve Solubility mentioning

confidence: 99%

“…The presence of these nanoparticles in the metabolic pathway causes oxidative stress, enzyme inhibition, protein deactivation and altered membrane permeability, electrolyte balance, and gene expression, which results in microbial death [153]. Most commonly, silver (Ag), gold (Au), copper (Cu) zinc oxide (ZnO), and titanium dioxide (TiO 2 ) nanoparticles were incorporated into chitosan-based wound dressings, to enhance antibacterial activity [5,126,[154][155][156][157][158][159]. Ag and Au nanoparticles reduce oxygen molecules, to form reactive intermediates with strong positive redox potential, such as superoxide and hydroxyl radicals (Ag nanoparticles), and singlet oxygen (Au nanoparticles).…”

Section: Chitin and Chitosan Nanocomposite Architectures As Wound Drementioning

confidence: 99%

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Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

et al. 2020

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Chitin and its derivative chitosan are popular constituents in wound-treatment technologies due to their nanoscale fibrous morphology and attractive biomedical properties that accelerate healing and reduce scarring. These abundant natural polymers found in arthropod exoskeletons and fungal cell walls affect almost every phase of the healing process, acting as hemostatic and antibacterial agents that also support cell proliferation and attachment. However, key differences exist in the structure, properties, processing, and associated polymers of fungal and arthropod chitin, affecting their respective application to wound treatment. High purity crustacean-derived chitin and chitosan have been widely investigated for wound-treatment applications, with research incorporating chemically modified chitosan derivatives and advanced nanocomposite dressings utilizing biocompatible additives, such as natural polysaccharides, mineral clays, and metal nanoparticles used to achieve excellent mechanical and biomedical properties. Conversely, fungi-derived chitin is covalently decorated with -glucan and has received less research interest despite its mass production potential, simple extraction process, variations in chitin and associated polymer content, and the established healing properties of fungal exopolysaccharides. This review investigates the proven biomedical properties of both fungal- and crustacean-derived chitin and chitosan, their healing mechanisms, and their potential to advance modern wound-treatment methods through further research and practical application.

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Section: Derivatization Of Chitin and Chitosan To Improve Solubility mentioning

confidence: 99%

Section: Chitin and Chitosan Nanocomposite Architectures As Wound Drementioning

confidence: 99%

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

et al. 2020

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“…PVA is a biocompatible and nontoxic polymer that has innumerous applications as a biomaterial (Gao et al, ; Gupta et al, ; Khorasani, Joorabloo, Adeli, Mansoori‐Moghadam, & Moghaddam, ; Liu et al, ; Teodorescu et al, ). Due to its excellent film‐forming properties and hydrophilic feature, PVA has been used as component of tissue engineering scaffolds in order to provide suitable strength and adhesive properties to support cell growth (Gupta et al, ; Liu et al, ; Rodríguez‐Rodríguez, García‐Carvajal, Jiménez‐Palomar, Jiménez‐Avalos, & Espinosa‐Andrews, ; Teodorescu et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Although its hydrophilic nature shows several advantages for cell culture, it is also challenging to avoid rapid dissolution of PVA‐based materials in aqueous media while maintaining suitable culture conditions. Water‐resistant alternatives described in the literature include blends made of PVA and natural polymers (e.g., chitosan, alginate, and gelatin; Bendtsen, Quinnell, & Wei, ; Khorasani et al, ; Rodríguez‐Rodríguez et al, ), or PVA hydrogels obtained from freeze/thaw cycles (Chee, de Goetten Lima, Devine, & Nugent, ; Khorasani et al, ; Liu et al, ; Rodríguez‐Rodríguez et al, ), which result in physical cross‐linking between the polymer chains. Other alternatives include chemical cross‐linking with glutaraldehyde, and acrylates (Morandim‐Giannetti et al, ; Ossipov, Piskounova, & Hilborn, ).…”

Section: Discussionmentioning

confidence: 99%

“…PVA is a biocompatible and nontoxic polymer that has innumerous applications as a biomaterial (Gao et al, 2019;Gupta et al, 2011;Khorasani, Joorabloo, Adeli, Mansoori-Moghadam, & Moghaddam, 2019;Liu et al, 2009;Teodorescu et al, 2019). Due to its excellent film-forming properties and hydrophilic feature, PVA has been used as the free OH groups of the polymer, giving rise to ester linkages (Harifi & Montazer, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Interaction of fibroblasts and induced pluripotent stem cells with poly(vinyl alcohol)‐based hydrogel substrates

et al. 2019

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Induced pluripotent stem cells (iPSCs) provide a promising means of creating custom‐tailored cell lines for cellular therapies. Their application in regenerative medicine, however, depends on the possibility that the maintenance and differentiation of cells and organs occur under defined conditions. One major component of stem cell culture systems is the substrate, where the cells must attach and proliferate. The present study aimed to investigate the putative cytotoxic effects of poly(vinyl alcohol) (PVA)‐based matrices on the in vitro culture of mouse fetal fibroblasts. In addition, the PVA‐based hydrogels were used to determine the capacity of bovine induced pluripotent stem cells (biPSCs) to adhere and proliferate on synthetic substrates. Our results show that both cell types interacted with the substrate and presented proliferation during culture. The biPSCs formed new colonies when cell suspensions were placed onto the hydrogel surface for culture. These results may represent a new characterized xeno‐free clinical grade culture system to be widely applied in cell‐based therapies.

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Ellagic acid loaded nanospheres/biodegradable PVA‐sodium alginate hydrogel for wound healing application

Kabirian Kholghi,

Tamri,

Haddadi

et al. 2023

J of Applied Polymer Sci

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In the present study, a novel polyvinyl alcohol‐sodium alginate hydrogel was prepared using ellagic acid loaded nanospheres in its structure. Ellagic acid was loaded into polymeric nanospheres using a double‐emulsion solvent evaporation technique. Obtained nanospheres were dispersed in a polyvinyl alcohol‐sodium alginate hydrogel, prepared using freeze–thaw method followed by freeze‐drying. Ellagic acid loaded nanospheres and the final hydrogel preparation were characterized using scanning electron microscopy, dynamic light scattering, and Fourier transformation infrared spectroscopy, and investigated for ellagic acid content, and release profile. MTT assays were conducted to measure the viability of cells after treatment with the hydrogel, and wound healing activity was investigated through in vivo studies on open wounds of an animal model. Results showed formation of nanospheres with average diameter of 241.5 nm and prolonged‐release profile of ellagic acid during 48 h. MTT assays showed a significant increase in cell proliferation upon treatment of NIH3T3 cells with the hydrogel. The hydrogel also significantly increased the rate of wound closure through improved epithelialization and production of collagen fibers. It can be concluded that the hydrogel containing ellagic acid‐loaded nanospheres prepared in this study can be designated as a biocompatible dressing to accelerate the wound healing process.

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Design and optimization of process parameters of polyvinyl (alcohol)/chitosan/nano zinc oxide hydrogels as wound healing materials

Cited by 168 publications

References 43 publications

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

Interaction of fibroblasts and induced pluripotent stem cells with poly(vinyl alcohol)‐based hydrogel substrates

Ellagic acid loaded nanospheres/biodegradable PVA‐sodium alginate hydrogel for wound healing application

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