Design and Optimization of Stimuli-responsive Emulsion-filled Gel for Topical Delivery of Copaiba Oil-resin

Campanholi, Katieli da Silva Souza; Silva, Jéssica Bassi da; Batistela, Vagner Roberto; Gonçalves, Renato Sonchini; Santos, Rafaela Said dos; Balbinot, Rodolfo Bento; Lazarin-Bidóia, Danielle; Bruschi, Marcos Luciano; Ueda-Nakamura, Tânia; Nakamura, Celso Vataru; Caetano, Wilker

doi:10.1016/j.xphs.2021.10.003

Cited by 14 publications

(10 citation statements)

References 23 publications

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“…Moreover, the simultaneous presence of aqueous and oily phases may provide convenient reservoirs for both lipophilic and hydrophilic APIs and excipients, making such emulsion an interesting vehicle ready to be transformed into a complex drug form. It is worth noting that the general idea of thermosensitive, poloxamer-based emulgels as drug preparations is not limited to lipophilic APIs dissolved in refined oils but is also open for an incorporation of natural oily extracts and oleoresins of specific pharmaceutical activity, as shown by Campanholi et al in their recent paper [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the proposed oil phase content was 0.25 to 0.75%, making it a quite different kind of formulation from the one presented in this paper. The third and most interesting case was published recently by Campanholi et al [ 37 ]. Here, poloxamer 407 was applied in concentrations within 18% to 22% as an emulsifier and thermogelling agent in compositions with 0.2–0.3% of Carbopol and 15–25% of Copaiba oleoresin used as an oily active substance.…”

Section: Introductionmentioning

confidence: 99%

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Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

2021

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This article covers the design and evaluation of a novel drug vehicle: a thermosensitive, injectable, high-oil-content (50% w/w) emulgel providing a controlled release of lipophilic pharmaceuticals. Different vegetable (castor, canola, olive, peanut, grapeseed, linseed), mineral (paraffin) and semisynthetic (isopropyl myristate, oleic acid) oils were screened for ibuprofen (IBU) solubility and for their capacity for high-shear emulsification in a 17% (w/w) aqueous solution of poloxamer 407. Chosen emulgels were subject to a rheological evaluation, a syringeability test (TA.XT texture analyser; 2 mL syringe; 18 G, 20 G and 22 G needles) and a drug release study (48 h; cellulose membrane; 0.05 mol/L phosphate buffer at pH 7.4). Castor oil turned out to be an optimal component for IBU incorporation. Blank and drug-loaded castor oil emulgels were susceptible to administration via a syringe and needle, with the absolute injection force not exceeding 3 kg (29.4 N). The drug release test revealed dose-dependent, quasi-linear kinetics, with up to 44 h of controlled, steady, linear release. The results indicate the significant potential of high-oil-content, oil-in-water thermosensitive emulgel formulations as vehicles for the controlled release of lipophilic APIs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

2021

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“…The work proposed by the University of Maringá certainly has high market potential. 10,31,32 Figure 4 reports all the benefits of copaiba oil in dermatological treatments. Observations indeed resulted in the selection of the therapeutic oil in many Brazilian kinds of research.…”

Section: Stimulant-responsive Formulations For the Treatment Of Cutan...mentioning

confidence: 99%

“…Thus, the authors suggested that the lower limit of the components is promising in further design and optimization studies. 10 Figure 5 shows a photograph donated by the authors that shows the extensive study to improve the formulation with copaiba oil.…”

Section: Stimulant-responsive Formulations For the Treatment Of Cutan...mentioning

confidence: 99%

“…6 Dermatological treatments can be achieved using herbal formulations therapeutically based on copaiba oil-resin (COR). [7][8][9][10] COR is a medicinal bioactive approved by the Food and Drug Administration (FDA) 11,12 and commercialized in Brazil to combat more than 50 diseases, being included as a promisor agent against Sars-CoV-2 by molecular docking studies. 13 This mini-review aims to bring to the scientific community the potential of COR for several skin diseases treatment, especially cutaneous leishmaniasis.…”

Section: Introductionmentioning

confidence: 99%

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Minireview about Medicinal Copaiba Oil in the Treatment of Skin Diseases

Campanholi¹,

Júnior²,

Braga³

et al. 2022

J Dermatol & Skin Sci

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The therapeutic benefits of copaiba oil-resin have encouraged its use in developing dermatological emulsions. Here, the anti-inflammatory, healing, antimicrobial, analgesic, and permeation-promoting properties of this medicinal oil are shown by reviewing articles from 2005 to 2021. Their properties encourage research to develop an herbal medicinal effective in treating skin diseases and cutaneous leishmaniasis.

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Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage forms: A brief review

Estabragh

Bami

Dehghannoudeh

et al. 2023

International Journal of Biological Macromolecules

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Design and Optimization of Stimuli-responsive Emulsion-filled Gel for Topical Delivery of Copaiba Oil-resin

Cited by 14 publications

References 23 publications

Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

Minireview about Medicinal Copaiba Oil in the Treatment of Skin Diseases

Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage forms: A brief review

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