This study experimentally investigates the impact of low pore density and thickness on the flow resistivity, hence permeability, of periodic open porous materials. An experimental setup is developed to measure the flow resistivity of porous samples adhering to the guidelines provided by the International Standards Organization 9053 and American Society for Testing and Materials C522 standards. The flow resistivity of three different porous microlattices is considered. Two of the three lattices are obtained from a monospherical void subtraction method, while the third is the octet-truss lattice. The monospherical void geometries are body-centered-cubic and A15 lattices. The pore density, measured in terms of pores-per-inch (PPI), was varied from 1 PPI to 12 PPI for all three microlattices considered. At low PPIs, the pore sizes are on the order of macroscale thickness. Hence, the volume-averaging or homogenized equivalent fluid model may not be valid. The thickness variation for a fixed PPI is also considered over limits where traditional volume-averaging methods break down. It is shown that at extremely low PPIs and thicknesses, entrance and exit losses become dominant, and the flow resistivity measured as per standards ceases to be a constant with PPI or thickness. Furthermore, existing two-dimensional modeling approaches for losses due to flow in pipes are adopted to predict the entry and exit pressure loss coefficients for the considered microlattices with appropriate modifications.