Design and performance of 0.18-/spl mu/m CMOS charge preamplifiers for APD-based PET scanners

Robert, S.; Pratte, J.‐F.; DeGeronimo, Gianluigi; O’Connor, P.; Stoll, S. P.; Pépin, C.; Fontaine, R.; Lecomte, Roger

doi:10.1109/tns.2004.836120

Cited by 44 publications

(17 citation statements)

References 20 publications

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“…To improve the performance of the detector, many modifications have been made to the front-end ASIC ( Fig. 1(c)) leading to a measured Equivalent Noise Charge (ENC) of ~ 650 electrons rms, a factor of ~2 improvement over the ENC achieved by the original design [12], [14]. The Charge Sensitive Preamplifier (CSP) was completely redesigned.…”

Section: A New Ratcap Designmentioning

confidence: 99%

A Simultaneous PET/MRI scanner based on RatCAP in small animals

Schlyer¹,

Vaska²,

Tomasi³

et al. 2007

2007 IEEE Nuclear Science Symposium Conference Record

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Abstract-The ability to acquire high resolution anatomical data as well as quantitative functional information in vivo is becoming an increasingly important factor in the diagnosis of disease. Simultaneous acquisition of PET and MRI data would provide essentially perfect co-registration between the two images which is particularly important for tissues whose position and shape can change between sequential scans. RatCAP is a complete 3D tomograph that is designed to image the brain of an awake rat. A special MRI coil composed of 2 saddle elements working in quadrature mode was mounted on a Delrin cylinder specifically designed to fit inside the RatCAP but allowing the rat's head to be placed inside as well. Simultaneous PET/MRI images of the rat brain have been acquired in a 4T MRI scanner using the RatCAP detector, with minimal effect on MRI images.

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Section: A New Ratcap Designmentioning

confidence: 99%

A Simultaneous PET/MRI scanner based on RatCAP in small animals

Schlyer¹,

Vaska²,

Tomasi³

et al. 2007

2007 IEEE Nuclear Science Symposium Conference Record

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“…The signal issued from the APD are amplified with a charge sensitive preamplifier (CSP), designed in CMOS P18 technology [8], and digitized with offthe-shelf 45 MSPS 8-bit ADC (Fig 1). An FPGA harvests samples and performs relevant feature extraction like energy, timestamping and crystal identification (CI) prior to sending such information to scanner subsections coping with events sorting and coincidence extraction [3] [7].…”

Section: The Labpet™ Electronicsmentioning

confidence: 99%

Roadmap to fully-digital PET/CT scanners

Fontaine

Michaud

Leroux

et al. 2007

2007 IEEE Nuclear Science Symposium Conference Record

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The ever-increasing needs of molecular imaging now require significant upgrade of conventional PET and CT scanners. Upcoming research protocols ask for low doses, submillimeter resolution, high sensitivity and multimodality. Current scanner technologies are mainly based on analog ASICs having a long design-cycle which hinders rapid scanner improvements and can hardly keep up with the new requirements of biomedical research. With new high-speed processors and configurable electronics, combined with early digitization of the signals from detectors, digital signal processing can flexibly and concurrently deal with many of those requirements. The present paper highlights past, present and foreseen developments in PET/CT signal processing. In particular, different model fits, filtered interpolation and neural networks are compared for timestamping and pulse shape discrimination. Recursive (ARMAX, AR…) and non recursive (Wiener, Fast Fourier transforms, Wavelets…) filtering are compared for crystal identification. Advanced pile-up correction, baseline restoration and energy measurement in photon-counting CT are also discussed. Finally, new techniques dealing with realtime event processing for Compton-scatter LOR computation and alternate random estimation will be briefly introduced. Pros and cons of each method are discussed and the best methods identified for a roadmap to fully digital PET/CT scanning is presented

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“…The LabPET detection system consists in dual LYSO-LGSO phoswich crystals coupled individually to an APD (Table I) [3], [17]. A 16-channel CSP [18], which amplifies and shapes the signals, is wired to an off-the-shelf 45-Msps 8-bit dual channel ADCs. Such a sampling frequency leads to a 22.2 ns period between successive samples (Fig.…”

Section: Methodsmentioning

confidence: 99%

Timing Improvement by Low-Pass Filtering and Linear Interpolation for the LabPET Scanner

Fontaine

Lemieux

Viscogliosi

et al. 2008

IEEE Trans. Nucl. Sci.

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Digital processing for positron emission tomography (PET) scanners commonly relies on low frequency sampling ( 65 MHz) to reduce power consumption. Timestamps must then be interpolated between samples to achieve adequate time resolution for coincidence detection of annihilation radiation. A low-pass filter based interpolation algorithm adding up to 31 samples between original samples was designed to improve timing resolution of the LabPET scanner. A 2-bit refinement in the determination of the pulse maximum amplitude leads to a better estimation of the triggering threshold, which in turn enables a more accurate timestamp generation. Timestamp accuracy was investigated as a function of trigger level (15%-50% of maximum value). With the trigger threshold set at 20%, coincidence time resolution of 5 0 ns for LYSO-LYSO and 9 6 ns forLGSO-LGSO are obtained. A real time implementation of the algorithm was achieved in a Xilinx FPGA.

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Design and performance of 0.18-/spl mu/m CMOS charge preamplifiers for APD-based PET scanners

Cited by 44 publications

References 20 publications

A Simultaneous PET/MRI scanner based on RatCAP in small animals

A Simultaneous PET/MRI scanner based on RatCAP in small animals

Roadmap to fully-digital PET/CT scanners

Timing Improvement by Low-Pass Filtering and Linear Interpolation for the LabPET Scanner

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