Design and performance of an automated single column sequential extraction chromatographic system

Chung, Kun Ho; Kang, Dae-In; Rhee, Dong Seok

doi:10.1007/s10967-019-06642-2

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Individual, group or radionuclide/matrix separations represent an important part of the overall radionuclide determination scheme ( Figure 2). Numerous operations in chemical separation and purification can be introduced into flow systems; e.g., liquid-liquid extraction (LLE), liquid-liquid microextraction (LLME), solid phase extraction chromatography (SPEC), ion exchange chromatography (IEC), electrochemically modulated separations (EMS), capillary electrophoresis (CE) and molecularly imprinted polymer (MIP) separation [37,38,41,42,48,52,58,64,69,79,[82][83][84][85][86][87][88][89].…”

Section: Chemical Separation and Purificationmentioning

confidence: 99%

“…One of the main constraints in most commercial software packages is the high specificity for a certain configuration. To avoid the inconvenience, some in-house developed software based on LabVIEW [26,62,82], LabWindows [37,70,103,104] and Delphi plus Visual C++ (Autoanalysis software) [12,27,36,[42][43][44][45]47,53,61,105,106] respectively, has been widely applied in the radioanalytical field. In most cases of online radionuclide detection, signals from the detectors (e.g., LSC and ICP-MS) are directly collected and processed by standalone software associated with the detection instruments.…”

Section: Automation Of Flow Systemsmentioning

confidence: 99%

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Dynamic Flow Approaches for Automated Radiochemical Analysis in Environmental, Nuclear and Medical Applications

Qiao

2020

Molecules

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Automated sample processing techniques are desirable in radiochemical analysis for environmental radioactivity monitoring, nuclear emergency preparedness, nuclear waste characterization and management during operation and decommissioning of nuclear facilities, as well as medical isotope production, to achieve fast and cost-effective analysis. Dynamic flow based approaches including flow injection (FI), sequential injection (SI), multi-commuted flow injection (MCFI), multi-syringe flow injection (MSFI), multi-pumping flow system (MPFS), lab-on-valve (LOV) and lab-in-syringe (LIS) techniques have been developed and applied to meet the analytical criteria under different situations. Herein an overall review and discussion on these techniques and methodologies developed for radiochemical separation and measurement of various radionuclides is presented. Different designs of flow systems with combinations of radiochemical separation techniques, such as liquid–liquid extraction (LLE), liquid–liquid microextraction (LLME), solid phase extraction chromatography (SPEC), ion exchange chromatography (IEC), electrochemically modulated separations (EMS), capillary electrophoresis (CE), molecularly imprinted polymer (MIP) separation and online sensing and detection systems, are summarized and reviewed systematically.

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Section: Chemical Separation and Purificationmentioning

confidence: 99%

Section: Automation Of Flow Systemsmentioning

confidence: 99%

Dynamic Flow Approaches for Automated Radiochemical Analysis in Environmental, Nuclear and Medical Applications

Qiao

2020

Molecules

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“…Even so, there is still a potential risk of cross-contamination and memory effects, thus it is not an ideal solution for isotopic analysis. Recently, a single-column sequential extraction chromatographic system was reported [22]. It uses four peristaltic pumps to drive the eluent to control the flow rate.…”

Section: Introductionmentioning

confidence: 99%

An automated parallel multi‐channel chromatographic system for isotopic analysis – Demonstration considering Sr

Peng

et al. 2023

J of Separation Science

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A fully automated, closed‐column chromatographic system with parallel multi‐channel has been developed. This system is established with seven reagent reservoirs, one multi‐channel syringe pump, eight 10‐port valves, forty sample tubes, 40 columns, and a fraction collection tray. Four samples can be purified simultaneously at a time, and 40 samples can be purified in one batch. Each sample can be purified by an independent channel, avoiding cross‐contamination. The sample tubes can be flipped upside down for automatic cleaning, which eliminates the residue of samples. Moreover, the fraction collection tray can collect up to 104 different target components. The key performance of the system has been investigated. The results show that the sample tubes are well‐cleaned, the bubble does not affect the chemical behavior of columns, the consistency of the parallel channels is excellent and the blank of the system is negligible. The system was demonstrated by the purification of Sr from reference materials (BCR‐2, JB‐2, JB‐3, and NIST SRM 987). The recoveries of Sr are better than 89.4% and the blank of the whole procedure is less than 200 pg. The Sr isotope values agree well with the reference values.

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“…Several automated chromatography separation systems have been developed to reduce the personnel workload. − In fact, automated methods have long been successfully established and adopted in fields of traditional stable isotope analysis. − In recent years, the development and adoption of similar methods for radiogenic and non-traditional stable isotopes have also been developed, − where the eluent is controlled by a peristaltic pump or syringe pump. Among these pump-based systems, the commercialized fully automated ion exchange chromatography system prepFAST-MC (ESI, Omaha, NE, USA) has received increasing interest.…”

Section: Introductionmentioning

confidence: 99%

Development of an Automatic Column Chromatography Separation Device for Metal Isotope Analysis Based on Droplet Counting

Zhou

Miao

et al. 2021

Anal. Chem.

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A novel, simple, cost-effective, reliable, and practical automatic column chromatography separation device capable of simultaneously purifying samples for radiogenic and non-traditional stable isotope analysis has been developed. The device avoids the use of any pump and features eluent driving by the siphon effect (gravity) and quantitative control by infrared droplet counting. Several factors affecting the control of droplets were investigated, including types and concentrations of eluents and the height of the liquid level. Results showed that accurate dripping of the eluent could be readily achieved by controlling the number of droplets under selected conditions. The separation performance of the device was first demonstrated by the elution of Sr and Cd in synthetic matrix solutions. The recoveries of Sr and Cd samples were better than 87.6 and 95.0%, respectively, and the whole procedure blank was about 0.3 ng for Sr and 0.1 ng for Cd. Finally, the reliability of the device was further validated by the purification of Sr and Cd from different geological reference materials (NIST 2711a, Nod-A-1, BCR-2, and BHVO-2). The determined Cd and Sr isotope values agree well with their reference values within the uncertainty range. All these results clearly demonstrate the reliability and practicability of the proposed device, which provides a promising method for the automated purification of isotope samples.

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Design and performance of an automated single column sequential extraction chromatographic system

Cited by 4 publications

References 22 publications

Dynamic Flow Approaches for Automated Radiochemical Analysis in Environmental, Nuclear and Medical Applications

Dynamic Flow Approaches for Automated Radiochemical Analysis in Environmental, Nuclear and Medical Applications

An automated parallel multi‐channel chromatographic system for isotopic analysis – Demonstration considering Sr

Development of an Automatic Column Chromatography Separation Device for Metal Isotope Analysis Based on Droplet Counting

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