Pressure buildup/annular pressure buildup in subsea oil and gas equipment occurs primarily due to the thermal expansion of trapped liquids. With the advent of modern computers, it has become increasingly possible to numerically analyze such problems with commercial codes available in the market. The objective of the present study is to propose a methodology for numerical prediction of structural damage in subsea oil and gas equipment due to pressure buildup. A judicious combination of computational fluid dynamics (CFD) with structural finite element analysis code has been used to perform a sample numerical analysis that is truly representative of a wide class of problems encountered in subsea oil and gas applications. The mitigation of trapped pressure is one among the prime areas of concern in the subsea oil and gas industry. In the present study, CFD analysis is used to determine the maximum pressure buildup due to the thermal expansion of trapped liquids in small leak tight enclosed volumes with rigid walls and the pressure obtained is used as a boundary condition for the structural analysis. In a nutshell, the analysis has been split into three steps (1) a steady-state CFD analysis to determine the temperature distribution within the oil and gas equipment under consideration, (2) the temperature contours obtained from the steady-state analysis are imposed as a boundary condition for the transient analysis to calculate the trapped pressure in the small volumes of interest and finally and (3) a structural analysis is used to determine the damage to the oil and gas equipment. The methodology adapted is similar to a one-way coupled fluid structure interaction analysis, but provides the added advantage of a significant reduction in computational cost. In the present study, the proposed methodology has been extended to a subsea Christmas tree (XT) and the pressure buildup in the hydraulic lines has been calculated. The results obtained using the present technique has been compared with analytical solution. The proposed numerical technique can be applied to any subsea or surface oil and gas equipment where pressure buildup due to trapped volume is a major issue. The findings of this study can help for better understanding of pressure buildup in trapped volumes within subsea/surface oil and gas equipment. This study can be applied to predict the thermal expansion of trapped volumes in subsea XTs, manifolds, pipe line end manifolds (PLEM) and pipe line end termination (PLET) units.