Dankwoord xv C 1.3 Outline e rst part of this thesis provides a description of an optimization strategy for exure-based mechanisms, o ering a general framework for the optimization of the exure-based revolute, universal and spherical joint.Chapter 2 describes this optimization method speci cally developed for the optimization of exure mechanisms subjected to large deformations. In this chapter, Building block-based spatial topology synthesis method for large-stroke exure hingesAbstract Large-stroke exure mechanisms inherently lose sti ness in supporting directions when de ected. A systematic approach to synthesize such hinges is currently lacking. In this paper, a new building block-based spatial topology synthesis method is presented for optimizing large-stroke exure hinges. is method consists of a layout variation strategy based on a building block approach combined with a shape optimization to obtain the optimal design tuned for a speci c application.A derivative-free shape optimization method is adapted to include multiple system boundaries and constraints to optimize high complexity exure mechanisms in a broad solution space. To obtain the optimal layout, three prede ned threedimensional (3D) "building blocks" are proposed, which are consecutively combined to nd the best layout with respect to speci c design criteria. More speci cally, this new method is used to optimize a exure hinge aimed at maximizing the frequency of the rst unwanted vibration mode. e optimized topology shows an increase in frequency of a factor ten with respect to the customary three exure cross hinge (TFCH), which represents a huge improvement in performance. e numerically predicted natural frequencies and mode shapes have been veri ed experimentally.