To reduce the loss of a drive motor and improve the output efficiency of the drive motor, this paper explores the influencing factors of core loss of an embedded combined magnetic pole drive motor (ECMPDM) for new energy vehicles. The mathematical model of the core loss of the drive motor is established. The monitoring points are selected in different areas of the stator to analyze the distribution of magnetic density, and the correctness of the model is preliminarily verified. Taking the motor core loss as the primary objective of optimization, the multi-objective optimization of the stator slot structure size is carried out by the response surface analysis method. The average value of the stator core loss and the radial magnetic density amplitude of the B point is taken as the two optimization objectives, and the optimal solution of the model is selected by the Pareto frontier distribution diagram. The optimal stator structure is analyzed, and the core loss value is calculated by three methods and compared with the simulation value. The prototype experiments of the optimized motor are carried out, and the no-load core loss experiment, rated voltage characteristic experiment, and peak power characteristic experiment are carried out, which verify the rationality of the optimized size and structure of the embedded combined magnetic pole drive motor for new energy vehicles and provide a possibility for the analysis of the temperature field of the embedded combined magnetic pole drive motor for new energy vehicles.