2005
DOI: 10.1016/j.ijpharm.2004.07.021
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Design and process aspects of laboratory scale SCF particle formation systems

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Cited by 92 publications
(42 citation statements)
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“…Supercritical carbon dioxide (SC-CO 2 ), an excellent alternative to conventional organic chemical solvents, has found wide applications in organic synthesis, essential extraction, dyeing, particle formation, etc (Sihvonen et al 1999;Oakes et al 2001;Beckman 2004;Maeda et al 2004;Vemavarapu et al 2005;Herrero et al 2006). Over the past 10 years, the SC-CO 2 processing, one of the novel non-thermal food-processing techniques, has been the subject of intense scrutiny in view of the sterilisation of microorganisms and inactivation of enzymes, providing alternative functional properties and/or conservation of freshness (Damar & Balaban 2006).…”
mentioning
confidence: 99%
“…Supercritical carbon dioxide (SC-CO 2 ), an excellent alternative to conventional organic chemical solvents, has found wide applications in organic synthesis, essential extraction, dyeing, particle formation, etc (Sihvonen et al 1999;Oakes et al 2001;Beckman 2004;Maeda et al 2004;Vemavarapu et al 2005;Herrero et al 2006). Over the past 10 years, the SC-CO 2 processing, one of the novel non-thermal food-processing techniques, has been the subject of intense scrutiny in view of the sterilisation of microorganisms and inactivation of enzymes, providing alternative functional properties and/or conservation of freshness (Damar & Balaban 2006).…”
mentioning
confidence: 99%
“…In this context, SCF-based processes offer the possibility to design and prepare NPs without the limitations of traditional methods [610][611][612][613][614][615]. Working on these lines, two procedures were developed for NP preparations using SCF.…”
Section: Os-npsmentioning
confidence: 99%
“…Furthermore, on the basis of preliminary experiments and the literature, some experimental parameters were not varied or examined, e.g. continuous CO 2 flow (2,31), the collection filter (300-μm stainless steel slab) (12), multiple SC fluids (32), use of a nozzle (3,32,33), the use of a modifier (ethanol) (1,12) and the release rate into the precipitation chamber (12).…”
Section: Recovery Of Pgnmentioning
confidence: 99%