Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project

Tsuboi, Akito; Matsui, Hiroyuki; Shiraishi, Naoki; Murakami, Takahisa; Otsuki, Akihito; Kawashima, Junko; Kiyama, Tomomi; Tamahara, Toru; Goto, Maki; Koyama, Shihoko; Sugawara, Junichi; Metoki, Hirohito; Hozawa, Atsushi; Kuriyama, Shinichi; Tomita, Hiroaki; Kikuya, Masahiro; Minegishi, Naoko; Suzuki, Kichiya; Koshiba, S.; Tamiya, Gen; Fuse, Nobuo; Aoki, Yosuke; Toda, Takako; Ogishima, Soichi; Nakamura, Tomohiro; Sakurai‐Yageta, Mika; Nagami, Fuji; Kinoshita, Kengo; Kure, Shigeo; Shimizu, Ritsuko; Sasaki, Keiichi; Yamamoto, Masayuki

doi:10.1620/tjem.251.97

Cited by 3 publications

(26 citation statements)

References 18 publications

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“…A dental questionnaire was administered as reported (Tsuboi et al, 2020). Supragingival plaques were collected from right and left molar teeth [#16 and #26 under the Fedeŕation Dentaire Internationale (FDI) Two-Digit system] by a sterile Gracey curette and suspended in 1 ml saline in a standardized tube.…”

Section: Study Population Design and Samplesmentioning

confidence: 99%

“…On the day of the visit, participants completed an informed consent form and physiological measurements, oral examination and biospecimen collection were performed as reported (Kuriyama et al, 2016;Hozawa et al, 2020). A comprehensive whole mouth oral examination was performed by trained dentists, and details of oral examinations and dental questionnaires were as previously reported (Tsuboi et al, 2020).…”

Section: Study Design and Sample Collectionmentioning

confidence: 99%

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Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project

Saitō

Aoki

Tamahara

et al. 2021

Front. Cell. Infect. Microbiol.

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A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases.

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Section: Study Population Design and Samplesmentioning

confidence: 99%

Section: Study Design and Sample Collectionmentioning

confidence: 99%

Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project

Saitō

Aoki

Tamahara

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Despite limited evidence, this review suggested that earthquakes, as natural disasters, tend to have a negative impact on oral health. [14,24,25,[28][29][30] However, in 2 of the reviewed studies, no association between disasters and oral health was found. [26,27] Natural disasters are unpredictable and combined with the limited data currently available, it may be difficult to study and analyze their direct impact on oral health.…”

Section: Discussionmentioning

confidence: 99%

“…[14,[24][25][26][27][28][29][30] In 6 studies questionnaire surveys were performed to assess psychological status, lifestyle, medication, living condition, economic condition, and oral health behavior. [14,[25][26][27][28]30] Kishi et al used the General Oral Health Assessment Index scores to assess OHRQoL. [14,31] Four of the 6 studies assessed psychological distress status.…”

Section: Oral Health Assessment Methods and Timingmentioning

confidence: 99%

“…[14,24,25,[27][28][29][30] Furthermore, periodontal assessment was performed in 4 studies. [14,27,29,30] Sato et al investigated the loss of removable dentures related to the 2011 Great East Japan Earthquake. [25] In addition, 1 study reported the prevalence of oral Candida species in elderly victims of natural disasters.…”

Section: Oral Health Assessment Methods and Timingmentioning

confidence: 99%

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Impact of natural disaster on oral health: A scoping review

2023

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Natural disasters may affect oral health as a result of serious damage to social function and public health. However, no article has systematically summarized the impact of natural disasters on oral health. This review aimed to map the existing literature on the impact of natural disasters on oral health. Targeted literature was searched using PubMed, Web of Science, Cochrane Library, and CINAHL databases with the keywords "disaster" and "oral health." Eligibility criteria were established based on the Participant-Concept-Context model, and eligible studies were identified based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 flow diagram. Eight eligible studies related to earthquakes were included in this review. Of these, 7 studies were related to the 2011 Great East Japan Earthquake. Oral health status of victims of disaster was analyzed by assessing the following parameters: questionnaire surveys; examination for fungal infection; and analyses of the teeth, periodontal, and oral hygiene condition. Six studies suggested that natural disasters had a negative impact on oral health. Two studies could not determine the impact of natural disasters on oral health. Only 1 study analyzed the impact of disasters on oral health based on pre-and postdisaster surveys. This scoping review found that there was insufficient evidence to suggest a relationship between natural disasters and oral health and that there are biases in geographical areas and types of natural disasters in this research field. Further research is needed to promote evidence-based support by dental professionals during different disaster phases.Abbreviation: OHRQoL = oral health-related quality of life.

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Oral Health Interventions in Natural Disasters: A Scoping Review

Suzuki-Barrera,

Teramoto,

Sáez-Chandía

et al. 2023

Disaster med. public health prep.

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Objectives: This work aimed to identify, appraise, and summarize existing knowledge about oral health interventions in the context of natural disasters and verify the main research gaps. Methods: We searched in PubMed (National Library of Medicine, Maryland, USA), EMBASE (Elsevier, Amsterdam, Netherlands) and Epistemonikos (Epistemonikos Foundation, Santiago, Chile) until 2021 for primary studies and systematic reviews, assessing any oral health intervention in the context of natural disasters. The interventions were classified according to Cochrane Effective Practice and Organization of Care (EPOC) categories, and the type of natural disaster was defined according to the classification by the Centre for Research on the Epidemiology of Disasters (CRED). Results: We assessed a total of 19 studies (majorly in Japan, n = 8), all performed in the context of an earthquake or mixed natural disasters (earthquake and tsunami). Regarding interventions, 12 studies reported a promotional/ preventive intervention, with oral examination being the most frequent. 7 studies reported therapeutic interventions, mainly related to emergency management of fractures and injuries. Conclusions: The evidence accessed in our study was limited, highlighting the need for further research to focus on different oral health care interventions and outcomes in the context of different natural disasters, thus enhancing the formulation and implementation of recommendations and protocols worldwide.

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Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project

Cited by 3 publications

References 18 publications

Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project

Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project

Impact of natural disaster on oral health: A scoping review

Oral Health Interventions in Natural Disasters: A Scoping Review

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