Design and properties of novel gallium-doped injectable apatitic cements

Mellier, Charlotte; Fayon, Franck; Boukhechba, Florian; Verron, Elise; LeFerrec, Myriam; Montavon, Gilles; Lesoeur, Julie; Schnitzler, Verena; Massiot, Dominique; Janvier, Pascal; Gauthier, Olivier; Bouler, Jean‐Michel; Bujoli, Bruno

doi:10.1016/j.actbio.2015.05.027

Cited by 49 publications

(21 citation statements)

References 65 publications

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“…While osteoclastic lineage differentiation and resorption activity were lowered by gallium, no impact on viability and proliferation of osteoblasts was noted [ 143 ]. In an in vivo approach using a rabbit femoral defect model, gallium-loaded calcium phosphate cements showed no superiority over calcium phosphate cements without gallium in terms of bone healing, whereby the authors implied that no effect was observed due to the low resorption of the material and consequently, low release of Ga 3+ -ions [ 144 ]. In a subsequently conducted study, the gallium release from Ga-CaP was optimized and re-evaluated for its beneficial properties in bone healing.…”

Section: Metal Ions Their Physiological Functionalities and Role mentioning

confidence: 99%

Applications of Metals for Bone Regeneration

Glenske

Donkiewicz²,

Köwitsch³

et al. 2018

IJMS

180

125

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The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.

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Section: Metal Ions Their Physiological Functionalities and Role mentioning

confidence: 99%

Applications of Metals for Bone Regeneration

Glenske

Donkiewicz²,

Köwitsch³

et al. 2018

IJMS

180

125

View full text Add to dashboard Cite

show abstract

“…2a ). The structure of such CDA nanoparticles (Ca/P = 1.56, needle shape, length∼45 nm) was investigated in details by high-resolution solid-state NMR 60 , 61 . They are made of an ordered apatitic core with a disordered outer layer containing non-apatitic HPO 4 groups, adsorbed water molecules and deficient in hydroxyl ions.…”

Section: Resultsmentioning

confidence: 99%

Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field

Yon

Sarou‐Kanian

Scheler

et al. 2017

Sci Rep

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In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-selected images of rigid tissues and related biomaterials at very high magnetic field, with greatly improved signal to noise ratio and spatial resolution when compared to static conditions. Cross-polarization is employed to enhance contrast and to further depict spatially localized chemical variations in reduced experimental time. In these materials, very high magnetic field and moderate MAS spinning rate directly provide high spectral resolution and enable the use of frequency selective excitation schemes for chemically selective imaging. These new possibilities are exemplified with experiments probing selectively the 3D spatial distribution of apatitic hydroxyl protons inside a mouse tooth with attached jaw bone with a nominal isotropic resolution nearing 100 µm.

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“…Focusing on a synergistic use of biomaterials and cellular therapy in certain orthopedic disorders (e.g., osteoporosis), we have recently demonstrated that HA and doped HA nanoparticles are internalized through the spontaneous endocytosis pathways also by non‐phagocytic cells like mesenchymal stem cells without any negative effect on cell behavior . Since the anti‐resorptive ability of Ga ions is already assessed in literature, in this work our purpose is to examine, with a pilot in vitro study, the effect of Ga‐doped apatite phases on the induction of osteogenic related markers, alone and in association with Mg, on human ASCs. Our results showed that Ga‐doped HAs did not negatively affected cell morphology that maintained their fibroblast‐like (elongated spindle) morphology with abundant cytoplasm and large nuclei .…”

Section: Discussionmentioning

confidence: 99%

New hydroxyapatite nanophases with enhanced osteogenic and anti‐bacterial activity

Ballardini

Montesi

Panseri

et al. 2017

J Biomedical Materials Res

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This work describes the synthesis and characterization of new apatite phases co-doped with gallium, magnesium and carbonate, exhibiting osteogenic and antibacterial ability. The apatites are synthesized at low temperature to retain nanocrystallinity and controlled doping with the various bioactive foreign ions, as assessed by physico-chemical and crystallographic analyses, reporting the achievement of single phases with reduced crystal ordering. The analysis of single and multi-doped apatites reports to different mechanisms acting in the incorporation of gallium and magnesium ions in the apatite structure. The release of bioactive ions is correlated to the behavior of human mesenchymal stem cells and of different bacterial strands, selected among the most frequently affecting surgical procedures. Enhanced osteogenic and antibacterial ability is assessed in multi-doped apatites, thus suggesting potential future applications as new smart biomaterials integrating a significant boosting of bone regeneration with adequate protection against bacteria. © 2017 Wiley Periodicals Inc. J Biomed Mater Res Part A: 106A: 521-530, 2018.

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Design and properties of novel gallium-doped injectable apatitic cements

Cited by 49 publications

References 65 publications

Applications of Metals for Bone Regeneration

Applications of Metals for Bone Regeneration

Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field

New hydroxyapatite nanophases with enhanced osteogenic and anti‐bacterial activity

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