2017
DOI: 10.1016/j.cct.2016.12.023
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Design and rationale of Heart and Lung Failure – Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children

Abstract: Objectives Test whether hyperglycemic critically ill children with cardiovascular and/or respiratory failure experience more ICU-free days when assigned to tight glycemic control with a normoglycemic versus hyperglycemic blood glucose target range. Design Multi-center randomized clinical trial. Setting Pediatric ICUs at 35 academic hospitals. Patients Children aged 2 weeks to 17 years receiving inotropic support and/or acute mechanical ventilation, excluding cardiac surgical patients. Interventions Pat… Show more

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Cited by 16 publications
(13 citation statements)
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“…Severe hypoglycemia (blood glucose level, <40 mg per deciliter) that was considered by the investigators, according to prospectively defined criteria, 16 to be related to insulin administration occurred in 13 of 349 patients (3.7%) in the lower-target group, as compared with 1 of 349 (0.3%) in the higher-target group (P = 0.01). With the inclusion of instances in which severe hypoglycemia was considered to be unrelated to insulin administration, the total incidence was higher in the lower-target group than in the higher-target group (18 patients [5.2%] vs. 7 [2.0%], P = 0.03).…”
Section: Resultsmentioning
confidence: 99%
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“…Severe hypoglycemia (blood glucose level, <40 mg per deciliter) that was considered by the investigators, according to prospectively defined criteria, 16 to be related to insulin administration occurred in 13 of 349 patients (3.7%) in the lower-target group, as compared with 1 of 349 (0.3%) in the higher-target group (P = 0.01). With the inclusion of instances in which severe hypoglycemia was considered to be unrelated to insulin administration, the total incidence was higher in the lower-target group than in the higher-target group (18 patients [5.2%] vs. 7 [2.0%], P = 0.03).…”
Section: Resultsmentioning
confidence: 99%
“…16 Patients were randomly assigned, with the use of a central computer, to receive tight glucose control with a target of 80 to 110 mg per deciliter (lower-target group) or 150 to 180 mg per deciliter (higher-target group), with continuous intravenous insulin adjusted to maintain the blood glucose level in the target range. Randomization was performed according to a permuted-block design with stratification according to study site.…”
Section: Methodsmentioning
confidence: 99%
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“…16 Patients were randomly assigned, with the use of a central computer, to receive tight glucose control with a target of 80 to 110 mg per deciliter (lower-target group) or 150 to 180 mg per deciliter (higher-target group), with continuous intravenous insulin adjusted to maintain the blood glucose level in the target range. Randomization was performed according to a permutedblock design with stratification according to study site.…”
Section: Interventions and Outcomesmentioning
confidence: 99%
“…2A and Table 2). The measurements at the start of the intervention were also similar in the lower-target group and the higher-target group ( Severe hypoglycemia (blood glucose level, <40 mg per deciliter) that was considered by the investigators, according to prospectively defined criteria, 16 to be related to insulin administration occurred in 13 of 349 patients (3.7%) in the lower-target group, as compared with 1 of 349 (0.3%) in the higher-target group (P = 0.01). With the inclusion of instances in which severe hypoglycemia was considered to be unrelated to insulin administration, the total incidence was higher in the lower-target group than in the higher-target group (18 patients [5.2%] vs. 7 [2.0%], P = 0.03).…”
Section: Insulin Treatment and Blood Glucose Managementmentioning
confidence: 99%