Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study

Kim, Yong Jae; Lee, Jun-Young; Kwon, Sun U.; Lee, J.Y.; Kim, Y.J.; Seo, Woo‐Keun; Lee, S.H.; Lee, Y.S.; Kim, D.E.; Lee, J.H.; Rha, Joung‐Ho; Park, K.Y.; Heo, Sung Hyuk; Cho, K.H.; Kim, H.Y.; Kim, Y.D.; Cho, A.H.; Baik, Jong Sam; Lee, J.S.; Park, J.; Park, T.H.; Kim, E.G.; Koh, Im-Seok; Cha, Jae‐Kwan; Choi, Nack-Cheon; Kwon, Jee Hyun; Sohn, Sung Il; Lee, J.; Hwang, Yang Ha; Song, Hee‐Jung; Shin, Byoung‐Soo; Kim, J.T.; Lee, S.J.; Park, H.Y.; Ahn, Seong Hwan; Chung, Pil-Wook; Kwon, Soon-Bark; Sin, Dong-Yun; Do, Juyoung; Lee, S.B.; Lee, Y.B.; Yoo, Bong-Goo; Sung, Sang-Min; Kim, O.; Jung, Jun‐Sub; Lee, K.Y.; Jung, Yo Han

doi:10.1016/j.jstrokecerebrovasdis.2017.06.035

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Decrease in mean carotid IMT was significantly greater in the combo effects of the combination of cilostazol and probucol in comparison with cilostazol on coronary atherosclerosis showed negative result 23) . Ongoing PICASSO-IMT study 26) will evaluate effects of combination therapy with probucol and cilostazol on carotid IMT.…”

Section: Discussionmentioning

confidence: 99%

Effect of Probucol and/or Cilostazol on Carotid Intima Media Thickness in Patients with Coronary Heart Disease: A Randomized, Multicenter, Multinational Study

Kang

Kim

Sung

et al. 2021

JAT

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In a prospective randomized multinational open blinded endpoint study, the long-term effects of probucol or probucol and cilostazol with statin on carotid mean intima media thickness (IMT) were evaluated for the first time. Methods: Hypercholesterolemic patients with coronary artery disease were randomized to three groups and received study drugs for 3 years: the control with statin alone; the probucol group with statin and probucol; and the combo group with statin, probucol, and cilostazol. Primary efficacy endpoint was changes of mean carotid IMT at 3 years. Biomarkers, major adverse cerebro-cardiovascular events (MACCEs) and safety were secondary endpoints. Results: Two hundred eighty-one patients were randomized into three groups. All three groups showed significant regression of carotid IMT at 3 years compared with baseline. Decrease in mean carotid IMT was significantly greater in the combo group than in the control group at 1 year. However, there were no significant differences in changes of mean carotid IMT between groups at 3 years (control; −0.12 0.36 mm vs. probucol; −0.11 0.32 mm vs. combo; −0.16 0.38 mm). MACCEs were frequent in the control group, but the difference was not significant (control; 10.8% vs. probucol; 4.4% vs. combo; 6.9%, p 0.35). Probucol and cilostazol were well tolerated in long-term treatment without serious drug-related adverse reactions. Conclusion: Probucol or probucol and cilostazol with statin did not reduce carotid IMT in comparison with statin alone in this study. However, the clinical outcome of probucol-based treatment with current standard statin treatment may need further studies. reduce residual cardiovascular risk in addition to current standard lipid-lowering treatment with statin. In the "Investigate effect on Mean intima media thickness (IMT) of Probucol And/or CilosTazol in patients with coronary heart dIsease taking HMGCoA reductase inhibitor therapy (IMPACT on IMT)" study, we

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Section: Discussionmentioning

confidence: 99%

Effect of Probucol and/or Cilostazol on Carotid Intima Media Thickness in Patients with Coronary Heart Disease: A Randomized, Multicenter, Multinational Study

Kang

Kim

Sung

et al. 2021

JAT

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“…Values obtained in 3 tests were averaged and used to calculate FMD, i.e., FMD = [(D1-D0) / D0] × 100%, in which D0 represented the inner diameter of the brachial artery before reactive hyperemia, and D1 stood for the inner diameter of the brachial artery after reactive hyperemia. The IMT of the carotid artery was applied as a quantitative indicator for atherosclerosis (8,9).…”

Section: Evaluation Criteria Determination Of the Flow-mediated Dilat...mentioning

confidence: 99%

Correlations of High-frequency Ultrasound Evaluation of Brachial Artery Endothelial Dilatation and Carotid Atherosclerosis with Glucose and Lipid Metabolism, Inflammatory Cytokines, Severity of Coronary Artery Disease and Vascular Endothelial Function in Elderly Patients

Cheng¹,

Sun²,

Yin³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The study aimed to explore the correlations of the results of the high-frequency ultrasound evaluation of the brachial artery endothelial dilatation and carotid atherosclerosis with glucose and lipid metabolism, inflammatory cytokines, the severity of coronary artery disease (CAD) and vascular endothelial function in elderly patients. 78 elderly patients with CAD in Beijing Anzhen Hospital were selected. The highfrequency ultrasonography was carried out to observe the flow-mediated dilatation (FMD) and intimamedia thickness (IMT) and to analyze their correlations with inflammatory cytokines [C-reactive protein (CRP) and plasminogen activator inhibitor (PAI-1)], endothelial function [nitric oxide (NO) and endothelin-1 (ET-1)], glycolipid metabolism [high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG) and fasting blood glucose (FBG)] and the severity of CAD. FMD, NO and HDL-C: patients with single-vessel CAD> those with double-vessel CAD>those with multivessel CAD. IMT, CRP, PAI-1, FBG, ET-1, TC and TG: patients with single-vesselCAD< those with double-vessel CAD

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“…The range of the species was traditionally recognized as twelve subspecies, recently sunk into four [ 1 ]. The subspecies present in northeast Asia were assigned to P. b. chinesis and P. b. euptilrurus , and the latter is the only wild animal of the Felidae family that has survived in the Korean peninsula [ 1 2 ]. The leopard cat has been designated as an endangered wildlife species in Korea.…”

Section: Introductionmentioning

confidence: 99%

Fibrinous pleuritis associated with Streptococcus canis in a leopard cat (Prionailurus bengalensis euptilurus)

Seo,

Han,

Kim

et al. 2023

J Vet Sci

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Leopard cat ( Prionailurus bengalensis euptilurus ) is a small wild cat assessed as an endangered wildlife in Korea. There have been very few reports of their diseases. Herein, we describe fibrinous pleuritis caused by Streptococcus canis infection with excessive pleural effusion, hydropericardium, mild ascites, and liver fibrosis in a leopard cat. S. canis is a commensal microflora in domestic cats and often affects the upper respiratory tract inducing chronic and severe respiratory diseases. However, there is no literature regarding the S. canis in leopard cats. Therefore, we first report fibrinous pleuritis associated with an S. canis infection in a leopard cat.

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Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study

Cited by 4 publications

References 29 publications

Effect of Probucol and/or Cilostazol on Carotid Intima Media Thickness in Patients with Coronary Heart Disease: A Randomized, Multicenter, Multinational Study

Effect of Probucol and/or Cilostazol on Carotid Intima Media Thickness in Patients with Coronary Heart Disease: A Randomized, Multicenter, Multinational Study

Correlations of High-frequency Ultrasound Evaluation of Brachial Artery Endothelial Dilatation and Carotid Atherosclerosis with Glucose and Lipid Metabolism, Inflammatory Cytokines, Severity of Coronary Artery Disease and Vascular Endothelial Function in Elderly Patients

Fibrinous pleuritis associated with Streptococcus canis in a leopard cat (Prionailurus bengalensis euptilurus)

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