Design and research of bone repair scaffold based on two-way fluid-structure interaction

Fu, Mengguang; Wang, Fei; Lin, Guimei

doi:10.1016/j.cmpb.2021.106055

Cited by 26 publications

(19 citation statements)

References 43 publications

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“…Pore dimension is the main factor that determines fluid-induced WSS under perfusion flow ( Fu et al, 2021 ). Also, pore dimension is one of the factors that can influence cell attachment (e.g.…”

Section: The Role Of Scaffold Pore Geometry On the Cell Micro-mechanical Environmentmentioning

confidence: 99%

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Zhao

Xiong

Ito

et al. 2021

Front. Bioeng. Biotechnol.

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Mechanobiology research is for understanding the role of mechanics in cell physiology and pathology. It will have implications for studying bone physiology and pathology and to guide the strategy for regenerating both the structural and functional features of bone. Mechanobiological studies in vitro apply a dynamic micro-mechanical environment to cells via bioreactors. Porous scaffolds are commonly used for housing the cells in a three-dimensional (3D) culturing environment. Such scaffolds usually have different pore geometries (e.g. with different pore shapes, pore dimensions and porosities). These pore geometries can affect the internal micro-mechanical environment that the cells experience when loaded in the bioreactor. Therefore, to adjust the applied micro-mechanical environment on cells, researchers can tune either the applied load and/or the design of the scaffold pore geometries. This review will provide information on how the micro-mechanical environment (e.g. fluid-induced wall shear stress and mechanical strain) is affected by various scaffold pore geometries within different bioreactors. It shall allow researchers to estimate/quantify the micro-mechanical environment according to the already known pore geometry information, or to find a suitable pore geometry according to the desirable micro-mechanical environment to be applied. Finally, as future work, artificial intelligent – assisted techniques, which can achieve an automatic design of solid porous scaffold geometry for tuning/optimising the micro-mechanical environment are suggested.

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Section: The Role Of Scaffold Pore Geometry On the Cell Micro-mechanical Environmentmentioning

confidence: 99%

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Zhao

Xiong

Ito

et al. 2021

Front. Bioeng. Biotechnol.

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“…Scaffold surface area creates a proper environment for osteogenic differentiation by affecting parameters such as permeability and wall shear stress. 39…”

Section: Resultsmentioning

confidence: 99%

Biomechanical behavior of diamond lattice scaffolds obtained by two different design approaches with similar porosity; a numerical investigation with FEM and CFD analysis

Karaman

Asl

2022

Proc Inst Mech Eng H

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Scaffolds provide a suitable environment for the bone tissue to maintain its self-healing ability and help new bone-cell formation by creating structures with similar mechanical properties to the surrounding tissue. In the modeling of the scaffolds, an optimum environment is tried to be provided by changing the geometrical properties of the cell architecture such as porosity, pore size, and specific surface area. For this purpose, different design approaches have been used in studies to change these properties. This study aims to determine whether scaffolds with similar porosities modeled by different design approaches exhibit distinct biomechanical behaviors or not. By using the Diamond lattice architecture, two different design approaches were constituted. The first approach has constant wall thickness and variable cell size, whereas the second approach contains variable wall thickness and constant cell size. The usage of different design approaches affected the amount of specific surface area in models with similar porosity. Mechanical compression tests were conducted via finite element analysis, while the permeability performance of configurations with similar porosities (50%, 60%, 70%, 80%, and 90%) was evaluated by using computational fluid dynamics. The mechanical results revealed that the structural strength decreased with increasing porosity. Since their higher specific surface area causes lower pressure drops, the second group exhibits better permeability. In addition, it was found that to evaluate the wall shear stresses occurring on the scaffold surfaces properly, it is essential to consider the stress distributions within the scaffold rather than the maximum values.

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“…Bone tissue is the second most transplanted tissue, and as bone defects have a negative impact on patients’ health and quality of life, there is a great demand for bone substitute transplants. , In clinical treatment, autologous and allogeneic bone grafts have disadvantages and risks such as limited donors, many complications, and the possibility of disease transmission. − Grafting a bone scaffold with restorative and tissue-enhancing properties to replace injured tissue can circumvent various problems associated with autologous or allogeneic bone grafts. − Metals, polymers, ceramics, and composites are commonly used for artificial bone scaffolds. − Bioactive ceramics, on the other hand, have chemical and structural properties that are comparable to those of natural bone and are considered ideal for repairing bone tissue defects, making bioactive ceramic bone scaffolds a promising bone graft. ,, …”

Section: Introductionmentioning

confidence: 99%

Comprehensive Review on Fabricating Bioactive Ceramic Bone Scaffold Using Vat Photopolymerization

Liu

Wang

Liu³

et al. 2023

ACS Biomater. Sci. Eng.

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In recent years, bioactive ceramic bone scaffolds have drawn remarkable attention as an alternative method for treating and repairing bone defects. Vat photopolymerization (VP) is a promising additive manufacturing (AM) technique that enables the efficient and accurate fabrication of bioactive ceramic bone scaffolds. This review systematically reviews the research progress of VP-printed bioactive ceramic bone scaffolds. First, a summary and comparison of commonly used bioactive ceramics and different VP techniques are provided. This is followed by a detailed introduction to the preparation of ceramic suspensions and optimization of printing and heat treatment processes. The mechanical strength and biological performance of the VP-printed bioactive ceramic scaffolds are then discussed. Finally, current challenges and future research directions in this field are highlighted.

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Design and research of bone repair scaffold based on two-way fluid-structure interaction

Cited by 26 publications

References 43 publications

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Biomechanical behavior of diamond lattice scaffolds obtained by two different design approaches with similar porosity; a numerical investigation with FEM and CFD analysis

Comprehensive Review on Fabricating Bioactive Ceramic Bone Scaffold Using Vat Photopolymerization

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