Design and simulation of a helmet brain PET system

Wang, Tianquan; Niu, Meng; Huang, Chuan; Li, Yingguo; Yin, Yan; Chen, Ximeng

doi:10.1016/j.nima.2020.164470

Cited by 2 publications

(5 citation statements)

References 11 publications

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Section: Absolute Sensitivitysupporting

confidence: 82%

“…Thus, the enhanced solid angle coverage of the complete scanner allows for a two-to threefold improvement in peak sensitivity relative to the barrel module alone. Our reported sensitivity also compares favorably to the peak sensitivities of approximately 10% measured in the hemispherical scanner of Tashima et al [9] and the 7.34% predicted for the helmet scanner of Wang et al [11]. The increased sensitivity relative to Tashima et al [9] owes to our extended chin module, tight packing of detector arrays, and slightly wider energy window (the energy window for the scanner of Tashima et al is 400-600 keV).…”

Section: Absolute Sensitivitysupporting

confidence: 75%

“…That is, if the inner SiPM (i.e., the one closer to the patient) records a signal of amplitude S i , and the outer SiPM records a signal of amplitude S o , the fraction (S o − S i )/(S o + S i ) is strongly correlated with the DOI [22]. In a real scanner, a calibration between signal difference and DOI may be developed by emitting gamma rays into the sides of crystals at known depths [11]. We develop an analogous calibration in our simulation by plotting the actual value of the DOI versus (S o − S i )/(S o + S i ) , then fitting a third-order polynomial to this plot.…”

Section: Depth Of Interaction Resolutionmentioning

confidence: 99%

“…Using a similar hemispherical geometry without DOI capabilities, the group achieved a CTR of 245 ps [10]. In simulation of a non-depth encoding helmet brain PET using 1.5 × 1.5 × 10 mm 3 LYSO:Ce scintillator crystals, Wang et al predicted a global absolute sensitivity of 3.08 %, a peak sensitivity of 7.34 %, and a spatial resolution of 1.97 mm at the center of the field of view [11].…”

Section: Introductionmentioning

confidence: 99%

“…Scanner performance can be further improved by maintaining high solid angle coverage, using longer scintillator crystals (with lengths up to 30 mm), and using double-ended readout to accurately resolve DOI. The sensitivity of Tashima et alʼs scanner [9] was limited by substantial gaps between detector modules, while the sensitivities of Blackberg et al [12] and Wang et al [11] were limited by the stopping power of relatively short (15 mm) scintillator crystals. By using both high solid angle coverage and 30 mm-long crystals, we can maximize scanner sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Design and modeling of a high resolution and high sensitivity PET brain scanner with double-ended readout

Layden

Klein

Matava

et al. 2022

Biomed. Phys. Eng. Express

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In the wake of recent advancements in scintillator, photodetector, and low-noise fast electronics technologies, as well as in fast reconstruction software, positron emission tomography (PET) scanners have seen considerable improvements in spatial resolution, time resolution, and absolute sensitivity. To continue this trend, we present a helmet type PET brain scanner design that combines high solid angle coverage and double-ended readout of 30 mm-thick scintillator crystals to achieve excellent absolute sensitivity, depth of interaction resolution, and time resolution. This scanner comprises 598 detector arrays, each with 8×8 Lu1.8Y0.2SiO5:Ce (LYSO:Ce) crystals with dimensions 3.005×3.005×30 mm3 one-to-one coupled on either end to silicon photomultipliers (SiPMs). Our Monte Carlo simulations based in the platform Geant4 predict that this scanner would attain an absolute sensitivity to a 35 cm line source placed at the center of the radial field of view of (17.1±0.1) %, a depth of interaction resolution of (3.99±0.05) mm, and a coincidence time resolution of (198±5) ps. Our simulations also predict radial, tangential, and axial spatial resolutions at the center of the field of view of 3.3 mm, 3.1 mm, and 3.3 mm, respectively. As this set of simultaneous parameters compares favorably to today’s most advanced clinical PET scanners and other proposed designs, this scanner has a good chance of becoming a preferred tool for high quality brain imaging.

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Section: Absolute Sensitivitysupporting

confidence: 82%

Section: Absolute Sensitivitysupporting

confidence: 75%

Section: Depth Of Interaction Resolutionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design and modeling of a high resolution and high sensitivity PET brain scanner with double-ended readout

Layden

Klein

Matava

et al. 2022

Biomed. Phys. Eng. Express

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Design and Performance Evaluation of SiPM-based High-resolution Dedicated Brain Positron Emission Tomography Scanner: A Simulation Study

Zare,

Sheikhzadeh,

Teimourian Fard

et al. 2024

Journal of Medical Physics

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Purpose/Aim: The increasing population age highlights the critical need for early brain disease diagnosis, especially in disorders such as dementia. Consequently, a notable focus has been on developing dedicated brain positron emission tomography (PET) scanners, which offer higher resolution and sensitivity than whole-body PET scanners. This study aims to design and performance evaluation of an LYSO-based dedicated brain PET scanner. Materials and Methods: We developed a dedicated brain PET using Monte Carlo simulation based on cylindrical geometry. Each detector block consisted of a 23 × 23 array of 2 mm × 2 mm × 15 mm LYSO crystals coupled with SiPM. The performance of this scanner was evaluated based on the NEMA NU-2-2018 standard, focusing on analyzing various energy windows and coincidence time windows (CTWs). Results: The results demonstrated that the noise equivalent count rate (NECR) peaked at each CTW in the 408–680 keV energy window. In addition, increasing the CTWs from 3 ns to 10 ns resulted in a decrease of 9% in sensitivity and an increase of 63% in NECR. Furthermore, the study findings highlight that using a time-of-flight (TOF) resolution of 250 ps can substantially improve image contrast relative to non-TOF reconstruction. Conclusions: We conclude that employing a broader energy window and a narrower CTW can significantly enhance the scanner’s performance regarding sensitivity and NECR. Furthermore, incorporating LYSO pixelated crystals with TOF information will facilitate the generation of high-resolution and high-contrast images.

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Design and simulation of a helmet brain PET system

Cited by 2 publications

References 11 publications

Design and modeling of a high resolution and high sensitivity PET brain scanner with double-ended readout

Design and modeling of a high resolution and high sensitivity PET brain scanner with double-ended readout

Design and Performance Evaluation of SiPM-based High-resolution Dedicated Brain Positron Emission Tomography Scanner: A Simulation Study

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