Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology

Cao, Li; Mantell, Susan C.; Polla, Dennis L.

doi:10.1016/s0924-4247(01)00680-x

Cited by 163 publications

(77 citation statements)

References 20 publications

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“…As such, it does not apply to peristaltic micropumps whose channel wall motion is coupled to fluid flow. Analytical and numerical calculations of static diaphragm deflections and pumping stroke volumes have been considered for piezoelectric peristaltic micropumps [25]. Also restricted to static characteristics, piezoelectric [4] and electrostatic [26] peristaltic pumps have been modeled by assuming the flow rate to be proportional to the actuation frequency and stroke volume, which is determined from the diaphragm motion by ignoring its interaction with fluid flow.…”

Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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This paper presents lumped-parameter simulation of dynamic characteristics of peristaltic micropumps. The pump consists of three pumping cells connected in series, each of which is equipped with a compliant diaphragm that is electrostatically actuated in a peristaltic sequence to mobilize the fluid. Diaphragm motion in each pumping cell is first represented by an effective spring subjected to hydrodynamic and electrostatic forces. These cell representations are then used to construct a system-level model for the entire pump, which accounts for both cell-and pump-level interactions of fluid flow and diaphragm vibration. As the model is based on first principles, it can be evaluated directly from the device's geometry, material properties and operating parameters without using any experimentally identified parameters. Applied to an existing pump, the model correctly predicts trends observed in experiments. The model is then used to perform a systematic analysis of the impact of geometry, materials and pump loading on device performance, demonstrating its utility as an efficient tool for peristaltic micropump design.

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Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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“…In [23] the design of an implantable micro pump for drug delivery is presented. The simulation and mechanical analysis of proposed micro pump is done.…”

Section: Drug Delivery Mechanismsmentioning

confidence: 99%

“…Many delivery mechanisms are designed and investigated. These methods include targeted drug delivery using Microrobot, drug delivery by focused ultrasound in case of central nervous system diseases, drug delivery by micropumps mechanism [19,23,26].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Study on Design Trends and Future Scope of Implantable Drug Delivery Systems

Ramesh¹,

Gupta²,

Ahmed³

et al. 2017

IJBSBT

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“…[3][4][5] Among them, piezoelectric active micro-valve were suitable for medical application, with advantages, such as low power consumption, good reliability and energy efficiency. 2,6,7 In traditional piezoelectric active micro-valve, piezoelectric vibrator is normally used as a valve stopper to keep the channel closed or open directly, since the displacement of piezoelectric vibrator is small, the flow capacity and particle tolerance is low. [8][9][10][11] In order to obtain the structure with large displacement and small size, the micro-valves based on piezoelectric and hydraulic amplification mechanism have been presented.…”

Section: Introductionmentioning

confidence: 99%

A normally-closed piezoelectric micro-valve with flexible stopper

et al. 2016

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In the field of controlled drug delivery system, there are still many problems on those reported micro-valves, such as the small opening height, unsatisfactory particle tolerance and high cost. To solve the above problems, a novel normally-closed piezoelectric micro-valve is presented in this paper. The micro-valve was driven by circular unimorph piezoelectric vibrator and natural rubber membrane with high elasticity was used as the valve stopper. The small axial displacement of piezoelectric vibrator can be converted into a large stroke of valve stopper based on hydraulic amplification mechanism. The experiment indicates that maximum hydraulic amplification ratio is up to 14, and the cut-off pressure of the micro-valve is 39kPa in the case of no working voltage. The presented micro valve has a large flow control range (ranging from 0 to 8.75mL/min).

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Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology

Cited by 163 publications

References 20 publications

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

A Comprehensive Study on Design Trends and Future Scope of Implantable Drug Delivery Systems

A normally-closed piezoelectric micro-valve with flexible stopper

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