Design and Study of Nanoceria Modified by 5-Fluorouracil for Gel and Polymer Dermal Film Preparation

Melnikova, Nina; Sheferov, Ilya; Panteleev, Dmitry; Emasheva, Anastasia; Druzhkova, Irina; Ignatova, Nadezhda; Mishchenko, Tatiana; Vedunova, Maria

doi:10.3390/ph16081082

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…В связи с этим высвобождение основывается на тестах оценки растворимости ЛВ. С другой стороны, высвобождение ЛВ из ЛФ чаще всего сводится к прониканию или массопереносу веществ из полимерной матрицы (оболочки таблеток и капсул, основы ТТС, гелей и полимерных дермальных пленок [4][5][6][7][8][9]) в некую среду (вода, 0,9%-й раствор хлорида натрия, буферные растворы, этанол, раствор циклодекстринов и др.) при P, T = const, обычно при нормальном атмосферном давлении и температурах 32 или 37 °С [4][5][6][7][8][9].…”

Section: Introductionunclassified

Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review)

Melnikova,

Sheferov,

Emasheva

et al. 2024

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. The review considered the basic concepts of drug release and kinetic modeling of this process from dosage forms (DF) according to the dissolution profile using a vertical Franz diffusion cell.Text. Drug release from dosage forms (ointments, gels, transdermal patches and polymer films) is usually described as the processes of drug dissolution in the biological system. Formally, this process, in accordance with pharmacopoeial methods, is assessed using various solubility tests. The theoretical aspects of drug release are based on the theory of mass transfer of substances from a polymer matrix into a system that simulates a biological environment. Drug release can be carried out via the passive diffusion mechanism according to Fick and "non-Fick" diffusion, drug desorption from the inner side of the membrane, as well as other mechanisms. Drug release is determined both lipophilicity and the membrane nature, both various physicochemical parameters of the drug. One of the correlation characteristics of mass transfer is the assessment of the permeability coefficient for a specific membrane that simulates skin. Permeability coefficient describes the rate of penetration of a drug per unit concentration in distance/time units. An example of relationship of "structure-permeability" correlation are the equations relating the permeability constant and lipophilicity to the molecular weight of the drug. The paper showed statistical methods of data analysis (MANOVA, ANOVA) and model-dependent methods (zero order, first order, Higuchi model, Korsmeyer – Peppas model, Hixson – Crowell model, etc.). The ideal drug delivery of non-degradable and non-disaggregating drugs describes as drug release model by zero-order reaction. For drug release of water-soluble drugs from a porous matrix, first-order reaction model is more typical. Kinetic models of fractional power functions are used usually as the cube root law (Hixson – Crowell model) or the square root law (Higuchi model) to describe the process of drug release from gels and dermal films and patches. The Korsmeyer – Peppas model allows us to evaluate the mechanism of mass transfer with Fickian diffusion or another process.Conclusion. Mathematical modeling of the drug release kinetics from soft dosage forms is an important element for the development and optimization of their compositions. The study of the drugs release from soft dosage forms, including TTS and polymer films, as well as the release from solid dosage forms, is based on establishing correlations between the kinetics of the release and dissolution profile. The main release models, regardless of the DF, remain the following models: zero order, first order, Korsmeyer – Peppas, Higuchi, Hickson – Crowell, the empirical or semi-empirical constants of which vary significantly depending on the DF and the release mechanism (Fickian diffusion or another drug mass transfer mechanism). Correlation relationships QSPeR or QSPR, using the coefficients of permeability, diffusion and lipophilicity, provide information on the mass transfer of drugs through the skin.

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Section: Introductionunclassified

Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review)

Melnikova,

Sheferov,

Emasheva

et al. 2024

Razrabotka i registraciâ lekarstvennyh sredstv

Self Cite

View full text Add to dashboard Cite

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Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Silina,

Manturova,

Erokhina

et al. 2023

RJTAO

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Objective: to analyze data on the synthesis and properties of cerium oxide nanoparticles, as well as the prospects of its application in regenerative medicine for wound healing. Methodology. World literature was reviewed using PubMed, SCOPUS, ResearchGate, CyberLeninck, and Elibrary databases, as well as manual searches for authors and reference lists. Key search terms were «cerium oxide» AND nano* AND (healing OR regeneration OR repair) AND wound». The timeline was from the date of publication through August 2023. Results. The final analysis included 59 sources containing information on the synthesis and size of nanoparticles (and/or other physicochemical characteristics), methodology and results of in vivo and in vitro studies on the efficacy and/or safety of nanoceria for wound regeneration. It is shown that despite the progressive growth of research interest over the last 15 years, the actual use of nanoceria in practical medicine is still not widespread. This is due to a wide variety of non-standardized synthesis methods and conditions, resulting in the variability of physicochemical parameters of nanoparticles (size, form), thereby affecting the safety and biomedical efficacy of nanoceria. Regeneration mechanisms, including the antioxidant-prooxidant, anti-inflammatory and antimicrobial effects of nanoceria, which contribute to accelerated wound healing, are discussed. The severity of the regenerative effects depends on the method and conditions of synthesis, hence the resulting physicochemical characteristics of the nanoparticles. Therefore, after each batch, newly synthesized nanoceria needs physicochemical and biomedical experimental tests. Conclusion. Nanoceria has great potential in tissue engineering for regenerative medicine, particularly for healing of various kinds of wounds. Having developed a technology for standardized synthesis for effective and safe nanoceria (of the right form and size) on a production scale, it can be introduced in medicine, possibly improving the outcomes of treatment of many diseases and pathologies. The authors present conclusions on the results of the study of nanoceria for accelerating qualitative regeneration and the requirements for nanoparticles obtained during synthesis.

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Design and Study of Nanoceria Modified by 5-Fluorouracil for Gel and Polymer Dermal Film Preparation

Cited by 2 publications

References 54 publications

Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review)

Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review)

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

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