Design and syntheses of 4-acylaminopyridine derivatives: Novel high affinity choline uptake enhancers II

Synthesis and Acetylcholinesterase/Butyrylcholinesterase Inhibition Activity of 4-Amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-Amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines

“…2,3-Dihydrofuro[2,3-b]quinolin-4amine (8) [12] was prepared by the titanium(IV) chloride catalyzed reaction between anthranilonitrile and γ-butyrolactone; this compound, as the others in the reported series, was claimed to have an AChE (IC 50 ) activities between 5 µM and 0.1 µM without assigning a specific values to defined molecules. It is interesting to point out that 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)acetoamide (MKC-231) (9) [13,14] showed no significant AChE inhibitory activity (probably due to the substitution of the nitrogen at C-4), but proved to be a powerful high affinity uptake enhancer.…”

[Bmim]BF4: A Versatile Ionic Liquid for the Synthesis of Diverse Bioactive Heterocycles

“…Pyridine nucleus is an important structural motif well distributed in numerous naturally occurring compounds. Some pyridine derivatives have been used as herbicides, fungicides, pesticides etc . Recently, cyanopyridines have gained considerable attention due to its interesting pharmacological and chemotherapeutic activities that include anticancer, antitubercular, antimicrobial activities.…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…Its derivatives have been designed and synthesized as therapeutic agents [21][22][23][24], as herbicides, fungicides, pesticides and as fluorescent dyes [25,26]. They have been commonly used as scaffolds for natural product synthesis (e.g., NAD nucleotides, pyridoxol (vitamin B6), and pyridine alkaloids) [27][28][29].…”