Design and synthesis of 1,4-dihydropyridine and cinnamic acid esters and their antioxidant properties

Gao, Yang; Wang, Bowei; Gao, Shang; Zhang, Ruhui; Yang, Chunying; Sun, Zheng; Liu, Zhihui

doi:10.1007/s40242-016-6047-0

Cited by 8 publications

(1 citation statement)

References 31 publications

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“…The results indicated the radical scavenging ability of 1,4-DHP rings as a hydrogen donor, which could be further enhanced by vanillin moieties. 76,77 The visual results agreed well with the quantitative data obtained by monitoring the absorbance at 734 nm of each solution (Figure S3). The half-maximal value of the inhibitory concentration (IC 50 ) of PVA-vanillin to ABTS +• was calculated as 56.8 μM, which is lower than that of PVA-ph (150.0 μM) (Figure S4a,b).…”

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Poly(vinyl alcohol) Modified via the Hantzsch Reaction for Biosafe Antioxidant Self-Healing Hydrogel

Pan

Zhang

et al. 2023

ACS Macro Lett.

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Efficient routes for the preparation of functional self-healing hydrogels from functional polymers are needed. In this study, we developed a strategy to effectively produce a vanillinmodified poly(vinyl alcohol) (PVA-vanillin) through the Hantzsch reaction. This polymer was cross-linked with a phenylboronic acidcontaining polymer (PB) that was also prepared using the Hantzsch reaction to fabricate a hydrogel through borate ester linkages under mild conditions (25 °C, pH ∼ 7.4). This hydrogel had excellent antioxidant abilities due to the 1,4-dihydropyridine (DHP) rings and the vanillin moieties in the hydrogel structures; it was also self-healable and injectable owing to the dynamic borate ester linkages. Furthermore, the antioxidant self-healing hydrogel had low cytotoxicity and exhibited favorable safety in animal experiments, indicating its potential as a safe implantable cell or drug carrier. This study developed a method for preparing functional polymers and related self-healing hydrogels in a facile manner; it demonstrated the value of the Hantzsch reaction in exploiting antioxidant self-healing hydrogels for biomedical applications, which may provide insight into the design of other functional self-healing hydrogels through different multicomponent reactions.

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Poly(vinyl alcohol) Modified via the Hantzsch Reaction for Biosafe Antioxidant Self-Healing Hydrogel

Pan

Zhang

et al. 2023

ACS Macro Lett.

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Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Merugu

Ansari

et al. 2023

Chemistry & Biodiversity

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An efficient 1,4‐dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4‐dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT‐29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in‐silico docking studies were conducted to understand the structure‐based features of the anticancer mechanism with the cancer medication target of Adenosine A2A receptor as well as the molecular level interactions of the compounds.

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Direct synthesis of heterocycles via MCRs, using a name reaction

Heravi¹,

Zadsirjan²

2020

Recent Advances in Applications of Name Reactions in Multicomponent Reactions

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Design and synthesis of 1,4-dihydropyridine and cinnamic acid esters and their antioxidant properties

Cited by 8 publications

References 31 publications

Poly(vinyl alcohol) Modified via the Hantzsch Reaction for Biosafe Antioxidant Self-Healing Hydrogel

Poly(vinyl alcohol) Modified via the Hantzsch Reaction for Biosafe Antioxidant Self-Healing Hydrogel

Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Direct synthesis of heterocycles via MCRs, using a name reaction

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