Design and synthesis of 3-(4-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as a novel class of analgesic and anti-inflammatory agents

Design and synthesis of quinazolinyl acetamides for their analgesic and anti-inflammatory activities

“…In our earlier studies [5,[12][13][14], we observed that the presence of aryl and methyl groups at C-2 position and various functional groups at N-3 substitution exhibited more analgesic and anti-inflammatory activities. In this continuation, N-3 modification was made by substitution in such a way to increase the lipophilicity of the molecule.…”

“…1, I) [12], 1-(2-phenylquinazolin-3-yl-4(3H)-one)-3-substituted thiourea (Fig. 1, II), 2,3-disubstituted quinazolines that exhibited good analgesic and anti-inflammatory activities [5,13,14]. The present work is an extension of our ongoing efforts towards the development and identification of new molecules for analgesic and anti-inflammatory activities with minimal gastrointestinal ulceration side effects.…”

A Three Component Synthesis of 2‐Aryl‐3‐imidamide Substituted 1,2‐Dihydroquinazolin‐4(1H)‐ones

“…[10] The enhanced polar surface area of this group of compounds are responsible for their versatile biological activity . [11] 1,2-Quinazo or dihydroquinazolinones bearing N À N linker i. e. N3 atom is substituted with an amino or an imino nitrogen are known to exhibit remarkable analgesic (compound V in Figure 1), [12][13][14] and anti-inflammatory (compounds VI-VII in Figure 1) [15][16][17][18] properties with their activity being comparable to standard anti-inflammatory agent proquazone (compound IV). Some C2 aryl substituted 1,2-dihydroquinazolinones inhibit tubulin polymerization and thus act as potential anticancer and antitumor agents (compounds VIII-IX in Figure 1).…”

Synthesis and Anticonvulsant Activity Evaluation of 4‐Phenyl‐[1,2,4]triazolo[4,3‐a]quinazolin‐5(4H)‐one and Its Derivatives

“…Quinazoline was first prepared in 1903, but breakthroughs in the late 20th century have increased its medicinal value . The pharmacology of quinazoline and quinazolinone derivatives is broad and they have been shown to possess anti‐inflammatory, antimicrobial, anticonvulsant, antiparasitic, and anticancer properties . The quinazoline motif has previously been referred to as the “master key” to antiepileptic therapy .…”