Design and synthesis of 3,5-diarylpiperidin-2,6-diones as anticonvulsant agents

Babu, M. Niranjan; Pitchumani, Kasi; Ramesh, P.

doi:10.1016/j.bmcl.2011.11.035

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…with significant SAR results. [56] The structural changes revealed the beneficial effect of the presence of 8-hydroxyquinol moiety for activity. These Mannich bases possesses average micromolar resistance for carcinoma cells.…”

Section: Synthesis Of "Antitumour" Moleculesmentioning

confidence: 99%

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Facile Multicomponent Mannich Reaction towards Biologically Active Compounds

Borah

Nath

et al. 2023

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The Mannich reaction is one of the most broadly used organic reactions for constructing CÀ N and CÀ C bonds in synthetic chemistry. This review focuses on the multicomponent Mannich reaction and its variants for the synthesis of biologically active moieties such as anticancer, antimicrobial, antimalarial, antitubercular, anti-inflammatory and anticonvulsant molecules. A few organocatalyzed asymmetric Mannich reactions are also incorporated.[a] Dr. P. Borah CSIO Analytical facility, (CAF)(a), CSIR-

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Section: Synthesis Of "Antitumour" Moleculesmentioning

confidence: 99%

“…al . reported a number of 8‐hydroxyquinoline‐based Mannich moieties and studied their spread inhibition with significant SAR results [56] . The structural changes revealed the beneficial effect of the presence of 8‐hydroxyquinol moiety for activity.…”

Section: Application Of Mannich Basesmentioning

confidence: 99%

Facile Multicomponent Mannich Reaction towards Biologically Active Compounds

Borah

Nath

et al. 2023

ChemistrySelect

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“…The currently available antiepileptic drugs phenytoin, mephobarbital induce side effects such as sedation and hypnosis. 63 There is ever-mounting need for new anticonvulsant agents to control all kinds of fits, with minimal or no side effects. Recently, Obniska et al reported the synthesis and studies of Mannich bases derived from [7,8-f ]benzo-2-azaspiro[4.5]decane-1, 3-dione and [7,8-f ]benzo-1,3-diaza-spiro-decane-2,4dione 78 (scheme 25).…”

Section: Synthesis Of Anticonvulsant Moleculesmentioning

confidence: 99%

Mannich reaction: A versatile and convenient approach to bioactive skeletons

Ganesan

2013

J Chem Sci

113

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This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here.

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