Design and Synthesis of 4,5-Disubstituted-thiophene-2-amidines as Potent Urokinase Inhibitors

<i>In vitro</i> Anti Leukemia Cancer Activity of Some Novel Pyrazole Derivatives and Pyrazoles Containing Thiazole Moiety

“…Nitrogen and sulphur heterocyclic compounds are extensively dispersed in natural world and are vital to life [1]. Among the wide range of heterocycles containing thiazole and pyrazolinone moeites investigated currently, heterocycles containing thiazole derivatives which have diverse biological activities [2][3][4][5][6][7][8][9][10][11]. Thiazole derivatives are remarkable in the biological activity of natural products and many potent biologically active molecules such as vitamine B1, sulphathiazole, abafungin and tiazofurin, epothilones, nizatidine and ritonavir [12][13][14][15][16][17][18][19][20][21][22][23].…”

Synthesis of tert-butyl (substituted benzamido)phenylcarbamate derivatives: anti-inflammatory activity and docking studies

“…Amide formation from carboxylic acids and amines is a fundamental reaction in organic, biological, medicinal, polymer, and material chemistry for which a great amount of research is still pursued [10]. The amide derivatives were associated with a broad spectrum of biological activities including anti-inflammatory [11], antidegenerative [12], antiplatelet [13], anticancer [14,15], antimicrobial [16][17][18], urokinase…”

Nickel(II) complexes of new polydentate carboxyamide: spectroscopic, kinetics of thermal decomposition and X-ray powder diffraction studies

“…Thus, we have designed amide ligands containing carboxylic anchors condensed with amidines. The amidine unit is the key functional group in a wide range of biologically active molecules [5], including a variety of serine protease inhibitors [6,7] and antimicrobial agents [8].…”