Design and synthesis of a highly sensitive “Turn-On” fluorescent organic nanoprobe for iron(<scp>iii</scp>) detection and imaging

Han, Cuiping; Huang, Tonghui; Liu, Qi; Xu, Huamin; Zhuang, Yinping; Li, Jingjing; Hu, Jinyan; Wang, Aming; Xu, Kai

doi:10.1039/c4tc01759e

Cited by 23 publications

(15 citation statements)

References 41 publications

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“…Han et al [57] introduced a novel naphthalimide-diethylenetriamine-quinoline-based fluorescent turn-on probe 50 for the selective detection of Fe 3+ that operated with AIEE and PET mechanisms. The weakly emissive 50 at 513 nm (λ exc = 403 nm) in pure CH 3 CN showed maximum fluorescence enhancement along with the red-shift from 513 to 524 nm in CH 3 CN containing 70% water due to the formation of nano-aggregates, and the red-shift is due to the restriction of intramolecular rotation.…”

Section: Fluorescent Turn-on Probes For Fe(iii)mentioning

confidence: 99%

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Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging

2019

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Iron(III) is well-known to play a vital role in a variety of metabolic processes in almost all living systems, including the human body. However, the excess or deficiency of Fe3+ from the normal permissible limit can cause serious health problems. Therefore, novel analytical methods are developed for the simple, direct, and cost-effective monitoring of Fe3+ concentration in various environmental and biological samples. Because of the high selectivity and sensitivity, fast response time, and simplicity, the fluorescent-based molecular probes have been developed extensively in the past few decades to detect Fe3+. This review was narrated to summarize the Fe3+-selective fluorescent probes that show fluorescence enhancement (turn-on) and ratiometric response. The Fe3+ sensing ability, mechanisms along with the analytical novelties of recently reported 77 fluorescent probes are discussed.

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Section: Fluorescent Turn-on Probes For Fe(iii)mentioning

confidence: 99%

“…The fluorescence images were acquired with green light excitation (Reproduced from Ref. [57] with permission from The Royal Society of Chemistry).…”

Section: Figures Schemes and Tablesmentioning

confidence: 99%

Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging

2019

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“…The abnormal amount of Fe 3+ ions can disturb the cellular homeostasis and induce serious disorders, including anemia, hemolytic disease, Parkinson's syndrome, Alzheimer's disease, and cancer . Tremendous efforts have been made to develop sensitive Fe 3+ monitoring approaches, including UV‐Vis spectrophotometry, inductively coupled plasma mass spectrometry, flame atomic absorption spectrometry, voltammetry, fluorescence spectrophotometry . Among these approaches, fluorescence spectroscopy is particularly promising owing to its simplicity, high sensitivity, and ability to facilitate real‐time detection.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Among these approaches, fluorescence spectroscopy is particularly promising owing to its simplicity, high sensitivity, and ability to facilitate real-time detection.…”

mentioning

confidence: 99%

Conjugated polymer nanoparticles with aggregation induced emission characteristics for intracellular Fe³⁺ sensing

Yang

Luo

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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In this article, a novel zwitterionic conjugated polyelectrolyte containing tetraphenylethene unit was synthesized via Pd-catalyzed Sonogashira reaction. The resulting polymer (P2), which exhibited typical aggregation-induced emission (AIE) properties, was weakly fluorescent in dilute DMSO solution and showed bright fluorescence emissions when aggregated in DMSO/water mixtures or fabricated into conjugated polymer nanoparticles (CPNs). The nanoparticles from P2 could be prepared by reprecipitation method with an average diameter around 23 nm. Notably, the cell-staining efficiencies of lipid-P2 nanoparticles could be enhanced with lipid encapsulation and these nanoparticles were endocytosed via caveolaemediated and clathrin-mediated endocytosis pathways. Furthermore, the lipid-P2 nanoparticles with low cytotoxicity, high photostability and efficient cell staining ability could be employed for in vitro detection of Fe 31 ions in A549 cells.

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“…Using naphthalimide-diethylenetriamine-quinoline (NDQ) derivatives as raw materials, Han, et al, 62 developed novel and high fluorescent organic nanoparticles (NDQ FONs) for turn-on 45 fluorescent detection of Fe 3+ (Fig. 5d).…”

Section: Nano-composite-based Fluorescent Sensingmentioning

confidence: 99%

Sensing materials developed and applied for bio-active Fe³⁺ recognition in water environment

Yan

You³

2016

Anal. Methods

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Design and synthesis of a highly sensitive “Turn-On” fluorescent organic nanoprobe for iron(iii) detection and imaging

Cited by 23 publications

References 41 publications

Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging

Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging

Conjugated polymer nanoparticles with aggregation induced emission characteristics for intracellular Fe³⁺ sensing

Sensing materials developed and applied for bio-active Fe³⁺ recognition in water environment

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Design and synthesis of a highly sensitive “Turn-On” fluorescent organic nanoprobe for iron(iii) detection and imaging

Cited by 23 publications

References 41 publications

Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging

Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging

Conjugated polymer nanoparticles with aggregation induced emission characteristics for intracellular Fe3+ sensing

Sensing materials developed and applied for bio-active Fe3+ recognition in water environment

Contact Info

Product

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Conjugated polymer nanoparticles with aggregation induced emission characteristics for intracellular Fe³⁺ sensing

Sensing materials developed and applied for bio-active Fe³⁺ recognition in water environment