Design and synthesis of a novel “turn-on” long range measuring fluorescent probe for monitoring endogenous cysteine in living cells and Caenorhabditis elegans

Wang, Kai; Wang, Wei; Guo, Mengya; Chen, Shi-Yu; Yang, Yu‐Shun; Wang, Bao‐Zhong; Xu, Chen; Zhu, Hai‐Liang

doi:10.1016/j.aca.2021.338243

Cited by 20 publications

(1 citation statement)

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“…Another strong electron-withdrawing group, 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF), had been reported to produce red-emitting D-A-type fluorophores. Therefore, the Zhu group developed a TCF-based long-range measuring probe 12 ( TCFQ-Cys ) for Cys detection, with acrylate serving as the response group [ 52 ]. The free probe 12 exhibited a turn-on response to Cys with a red emission at 633 nm; more excitingly, the emission intensity was linear to Cys concentrations throughout the wide range of 0–300 μM, covering the range of the physiological Cys level (30–200 μM), and the limit of detection was determined at 0.133 μM.…”

Section: Design Strategies For Specific Fluorescent Probes For Intrac...mentioning

confidence: 99%

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

et al. 2023

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Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. To this end, fluorescent probes have become increasingly popular due to their numerous advantages, including easy handling, desirable spatiotemporal resolution, high sensitivity, fast response, and favorable biocompatibility. As a result, intensive research has been conducted to create fluorescent probes for the detection and imaging of biothiols. This brief review summarizes recent advances in the field of biothiol-responsive fluorescent probes, with an emphasis on rational probe design, including the reaction mechanism, discriminating detection, reversible detection, and specific detection. Furthermore, the challenges and prospects of fluorescence probes for biothiols are also outlined.

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Section: Design Strategies For Specific Fluorescent Probes For Intrac...mentioning

confidence: 99%

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

et al. 2023

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Benzothiazole‐based fluorescent probe for N₂H₄

Hanlin

Huang

et al. 2022

Bulletin Korean Chem Soc

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A fluorescence enhancement probe 2‐[2‐(1,3‐benzothiazol‐2‐yl)phenyl]‐1H‐isoin‐dole‐1,3(2H)‐dione (HL1) for N2H4 was synthesized and characterized by using 2‐(2‐aminophenyl)benzothiazole as a fluorophore, and its spectroscopic properties had been researched. The results exhibited that HL1 was highly selective and sensitive to N2H4, and it had the excellent anti‐interference ability and displayed a fast response. The fluorescent intensity of HL1 showed a good linear relationship with the concentration of N2H4 (1.5–12.5 μmolL−1), and its detection limit was 0.12 μmol/L. In addition, HL1 was also applied for determining N2H4 levels in real water samples and imaging N2H4 in living HeLa cells.

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Visual and quantitative monitoring of thiophenol by a novel deep-red emitting fluorescent probe in environmental and biological systems

Erdemir

Oğuz

Malkondu

2023

Analytica Chimica Acta

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Design and synthesis of a novel “turn-on” long range measuring fluorescent probe for monitoring endogenous cysteine in living cells and Caenorhabditis elegans

Cited by 20 publications

References 57 publications

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

Benzothiazole‐based fluorescent probe for N₂H₄

Visual and quantitative monitoring of thiophenol by a novel deep-red emitting fluorescent probe in environmental and biological systems

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Design and synthesis of a novel “turn-on” long range measuring fluorescent probe for monitoring endogenous cysteine in living cells and Caenorhabditis elegans

Cited by 20 publications

References 57 publications

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

Benzothiazole‐based fluorescent probe for N2H4

Visual and quantitative monitoring of thiophenol by a novel deep-red emitting fluorescent probe in environmental and biological systems

Contact Info

Product

Resources

About

Benzothiazole‐based fluorescent probe for N₂H₄