Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

Allosteric Modulators of Potential Targets Related to Alzheimer's Disease: a Review

“…The nicotinic acetylcholine receptor (nAChR) is well known as a member of the ligand‐dependent superfamily of ion channels and can be found in neuronal cells. It is involved in several processes related to cognitive function, learning, memory, motor coordination, and analgesia …”

Combinatorial Chemistry Online Volume 16, Issue 7, July 2014

“…Starting from molecular docking studies on two series of molecules, an alternative scaffold was designed attempting to combine the optimal features of these previously identified urea and pyrazole compounds. A small library was synthesised in a parallel manner, affording compounds with excellent a7 nAChR activity, selectivity and a preliminary ADME profile was obtained [16].…”

Synthesis, characterization and evaluation of biological activities of some 2,3-diaryl bicyclo methanones

“…Methyl ketones and bicyclo methanones possess many pharmacological activities such as, AVP release and activation of vasopressin receptors [3], antimicrobial [4][5][6][7][8][9][10][11][12][13][14][15], cannabinoid receptor agonists [16], neuronal nicotinic acetylcholine receptors (nAChRs) [17], anti-inflammatory [12,13,18,19], analgesic [10,19], anticonvulsant [10,19], antitumor [19], anticancer [10], antiviral [19], anti-diabetic [10,20], antitubercular [20], antihelminthic [12,20], antidepressant [21], ulcerogenic [18], antinociceptive [10], protein tyrosine kinase inhibitor [22], DNA cleavage [23], Alzheimer's disease curing agent [24], antioxidant [25], acute toxicity [18], antihypertensive [10] and insect antifeedant activities [25]. Numerous solvent-free and solvent assisted synthetic methods with or without catalysts were reported in the literature for the synthesis of stereo selective monoand bicyclo-methanones [26][27]…”