Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety

Abstract

Developing an environmentally friendly and safe nanodelivery system is crucial to improve the efficacy of pesticides and minimize environmental and health risks. However, preparing a completely water-based nanopesticide without using harmful solvents is a technical challenge. In this study, a water-based nanodelivery pesticide system was constructed to improve the efficacy and safety of Emamectin Benzoate (EB). A specific surfactant, 29-(4-(5-hydroxynonan-5yl)phenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB) was designed and synthesized to form a water-based nanodelivery system (EBWNS) with EB. Molecular dynamics simulations revealed the self-assembly and interaction forces between SurEB and EB in water, providing insights into the formation mechanism of EBWNS nanoparticles. The nanodelivery system showed the prolonged effectivity of EB with reduced degradation and demonstrated a good control efficacy for multiple target pests, such as red spider mite, beet armyworm larvae (Lepidoptera: Noctuidae), and rice stem borers (Chilo suppressalis). Toxicology tests on various objects demonstrated that the EBWNS has low toxicity for seeds, HaCaT cells, zebrafish, earthworm, and E. coli. This study provides a distinctive perspective for developing environmentally friendly nanopesticide formulations, which clarified a water-based treatment method for specific lipid-soluble pesticides. The water-based nanodelivery pesticide system has the potential to improve the efficacy and safety of pesticides in the process of field applications.

Making the Complicated Simple: A Minimizing Carrier Strategy on Innovative Nanopesticides

“…The results indicate that the average value of target organism toxicity of NMC was 1.29 times that of NNC, suggesting that NMC may potentially offer efficacy advantages (Table S3). In terms of non-target organism toxicity, the water-only NMC system prepared by An et al [ 44 ] showed low toxicity to non-target plant seeds, human epithelial cells, zebrafish, earthworms, and Escherichia coli . Furthermore, the presence of prodrugs may also enhance biosafety.…”

Dual-loaded nano pesticide system based on industrial grade scaleable carrier materials with combinatory efficacy and improved safety

“…Therefore, due to the small size, BPDN is conducive to adhering to the leaf surface in a larger area, thereby improving pesticide droplets’ dispersing, wetting, and retention properties on the target crop leaves. In addition, nanoparticles play an important effect in the energy dissipation increase and pesticide droplets’ rebound behavior control on the leaf surface during the spraying process, which is beneficial for improving spraying performance and reducing the contact angle on the leaf surface [ 51 – 53 ]. The improved foliar performance of BPDN is conducive to reducing the loss and drift during the delivery process, and improving the utilization of formulations.…”