Design and synthesis of bioinspired nanomaterials for biomedical application

Abstract

Natural materials and bioprocesses provide abundant inspirations for the design and synthesis of high‐performance nanomaterials. In the past several decades, bioinspired nanomaterials have shown great potential in the application of biomedical fields, such as tissue engineering, drug delivery, and cancer therapy, and so on. In this review, three types of bioinspired strategies for biomedical nanomaterials, that is, inspired by the natural structures, biomolecules, and bioprocesses, are mainly introduced. We summarize and discuss the design concepts and synthesis approaches of various bioinspired nanomaterials along with their specific roles in biomedical applications. Additionally, we discuss the challenges for the development of bioinspired biomedical nanomaterials, such as mechanical failure in wet environment, limitation in scale‐up fabrication, and lack of deep understanding of biological properties. It is expected that the development and clinical translation of bioinspired biomedical nanomaterials will be further promoted under the cooperation of interdisciplinary subjects in future.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Emerging Technologies

Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications

“…To build biomimetic scaffolds for bone tissue engineering or to use mussel-inspired bioadhesives for skin wound healing, these methodologies imitate natural structures, such as the hierarchical structure of bone. The synthesis of BINMs might be divided into three categories ( Figure 6 ): synthesis inspired by natural structure/components, synthesis inspired by biomolecules, and synthesis inspired by bioprocesses [ 21 ].…”

“…The field of BINMs holds significant potential for scientific investigation; however, it is not devoid of inherent obstacles. One of the primary obstacles lies in the capacity to regulate the synthesis and assembly processes of these materials in order to attain the intended properties [ 21 ]. There exist additional concerns regarding the potential environmental and health ramifications associated with these nanomaterials, necessitating the need for further examination and comprehensive testing prior to their widespread implementation [ 22 ].…”