Design and synthesis of C3-symmetric molecules containing oxepine and benzofuran moieties via Metathesis

Design of Molecular Diversity by Olefin Metathesis in Tandem with Other Reactions

“…We succeeded in producing C3-symmetric oxepines 152 (81%) and 153 (86%) containing phenyl and triazine moieties after optimizing experimental conditions (Scheme 29). 25 Scheme 29 Synthesis of C3-symmetric oxepines 152 and 153 containing phenyl and triazine moieties.…”

Application of Olefin Metathesis in the Synthesis of Carbo- and Heteroaromatic Compounds—Recent Advances

“…Kotha reported a new synthetic strategy leading to C 3 -symmetric star-shaped phenyl and triazine central cores bearing oxepine and benzofuran ring systems [ 40 ]. The authors exploited a three-step procedure to construct C 3 -symmetric molecules, starting with the commercially available p -hydroxyacetophenone and p -hydroxybenzonitrile, through cyclotrimerization, double-bond isomerization, and ring-closing metathesis sequence as key steps.…”

An overview of the synthetic strategies ofC3-symmetric polymeric materials containing benzene and triazine cores and their biomedical applications

“…In order to get at the pyrrole-based star-shaped molecule, ringclosing metathesis (RCM) was employed. [57][58][59] Kotha et al demonstrated three different routes for synthesized pyrrolebased star-shaped C3-symmetric. RCM, Buchwald-Hartwig cross-coupling reaction, and Clauson-Kaas pyrrole synthesis were utilized as key steps.…”