Design and synthesis of curcumin-bioconjugates to improve systemic delivery

Kumar, Sanjay; Dubey, K. C.; Tripathi, Sarsij; Fujii, Masayuki; Misra, Krishna

doi:10.1093/nass/44.1.75

Cited by 26 publications

(8 citation statements)

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“…Two phenolic rings and active methylene groups are potential sites to conjugate any biomacromolecules onto curcumin. Kumar et al [37] designed nucleoside–curcumin bioconjugates to obtain high levels of glucuronide and sulfate curcumin conjugates in healthy human volunteers [38]. A recent patent technology based on a luteinizing hormone-releasing hormone (LHRH)–curcumin conjugate synthesized by fluorenylmethoxycarbonyl (Fmoc) solid phase has exhibited an improved antitumor effect in xenograft models of pancreatic cancer [39].…”

Section: Curcumin Nanocrystals and Conjugatesmentioning

confidence: 99%

Curcumin nanoformulations: a future nanomedicine for cancer

Yallapu

Jaggi

Chauhan

2012

Drug Discovery Today

617

407

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Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion, apoptosis and cell death, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and up-to-date solutions for improving curcumin bioavailability and anticancer potential for therapy.

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Section: Curcumin Nanocrystals and Conjugatesmentioning

confidence: 99%

Curcumin nanoformulations: a future nanomedicine for cancer

Yallapu

Jaggi

Chauhan

2012

Drug Discovery Today

617

407

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“…The curcumin derivatives are generally synthesized by derivatization, starting from curcumin. For example, the phenolic hydroxy group may be acylated, alkylated, glycosylated, demethylated and amino acylated [66][67][68][69][70]. Recently, Pana et al synthesized a novel curcumin analog (B06) that exhibited an improved pharmacokinetic and enhanced anti-inflammatory activity compared with curcumin in rat model [71].…”

Section: Curcumin Derivativesmentioning

confidence: 99%

Emerging role of nanocarriers to increase the solubility and bioavailability of curcumin

Mohanty

Das

Sahoo

2012

Expert Opinion on Drug Delivery

155

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“…Its rigid and electron-rich structure makes it an interesting candidate as a lead compound for further development of new inhibitors [30,31]. Several bioconjugates of curcumin have been synthesized to enhance the cellular uptake and targeted delivery of curcumin, thereby increasing curcumin's antibacterial potential [32,33].…”

Section: Introductionmentioning

confidence: 99%