2022
DOI: 10.1039/d2md00138a
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Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus

Abstract: Glycoconjugates are biologically significant molecules as they tend to serve wide range of intra and extra cellular processes depending on their sizes and complexities. The secondary metabolites of the plant...

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Cited by 15 publications
(10 citation statements)
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References 38 publications
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“…After completion of the reaction (TLC), the reaction mixture was evaporated in vacuo to obtain residue which was purified by flash chromatography using a RediSep column (SiO 2 , 12 g) with EtOAc‐petroleum ether mixture as eluent to furnish compound 2 a ‐ e . Spectral data of all the synthesized propargylated phenol were found to be consistent with the previous literature reports [7b,22] …”
Section: Methodssupporting
confidence: 88%
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“…After completion of the reaction (TLC), the reaction mixture was evaporated in vacuo to obtain residue which was purified by flash chromatography using a RediSep column (SiO 2 , 12 g) with EtOAc‐petroleum ether mixture as eluent to furnish compound 2 a ‐ e . Spectral data of all the synthesized propargylated phenol were found to be consistent with the previous literature reports [7b,22] …”
Section: Methodssupporting
confidence: 88%
“…The homo coupled 1,3‐diynes were characterized from their corresponding NMR spectra. In 1 H NMR spectrum of 3 a , the absence of acetylenic proton of 2 a (δ H 2.48 ppm) [7b] indicates the coupling of two units of propargylated eugenol 2 a . All the synthesized products were identified by their 1 H, 13 C NMR spectra and HRMS.…”
Section: Resultsmentioning
confidence: 99%
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“…4-allyl-2-methoxyphenol, also known as eugenol, is a volatile naturally occurring phenolic bioactive constituent in clove oil, nutmeg, and basil ( Ferreira et al., 2017 ). It possesses significant antioxidant, antifungal, and anti-inflammatory properties, in addition to analgesic and local anaesthetic activity ( Huang et al., 2015 ; Marchese et al., 2017 ; Goswami et al, 2022 ). This compound offers a number of therapeutic benefits via inhibition of generative reactive oxygen and nitrogen species, scavenging of free radicals, and disruption of microbial biofilms ( Khalil et al., 2017 ).…”
Section: Introductionmentioning
confidence: 99%