Design and synthesis of nano-biomaterials based on graphene and local delivery of cerebrolysin into the injured spinal cord of mice, promising neural restoration

Yari-Ilkhchi, Ayda; Mahkam, Mehrdad; Ebrahimi-Kalan, Abbas; Zangbar, Hamid Soltani

doi:10.1039/d3na00760j

Cited by 5 publications

(2 citation statements)

References 63 publications

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“…Other Hydrogels [180,181,253,254], PLGA [255] and PLA [256] Collagen [181,257], CS [258], silk [259,260], decellularised ECM [227], modified gelatine [261] R-GSIK [262], electrospun nanofiber nets [263] and gene scaffolds [264] Gold nanoparticle nerve guidance conduits [265] and collagen conduits [266] Graphene oxide [267], IGF-1 delivery via nanofibrous dural substitutes [197] and ROS scavenger materials [170,171] Table 2. Cont.…”

Section: Nerve Guidancementioning

confidence: 99%

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Stevens,

Belli,

Ahmed

2024

Biomedicines

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Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss of function that the central nervous system (CNS) cannot repair after the initial event is resolved. The way in which function is lost after injury is the consequence of a complex array of mechanisms that continue in the chronic phase post-injury to prevent effective neural repair. This review summarises the events after traumatic brain injury (TBI) and spinal cord injury (SCI), comprising a description of current clinical management strategies, a summary of known cellular and molecular mechanisms of secondary damage and their role in the prevention of repair. A discussion of current and emerging approaches to promote neuroregeneration after CNS injury is presented. The barriers to promoting repair after neurotrauma are across pathways and cell types and occur on a molecular and system level. This presents a challenge to traditional molecular pharmacological approaches to targeting single molecular pathways. It is suggested that novel approaches targeting multiple mechanisms or using combinatorial therapies may yield the sought-after recovery for future patients.

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Section: Nerve Guidancementioning

confidence: 99%

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Stevens,

Belli,

Ahmed

2024

Biomedicines

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“…PEG is a biocompatible, hydrophilic synthetic hydrogel that has non-toxic properties. During the acute phase of SCI, the application of hydrogel impedes the inflammatory response and reduces oxidative stress, diminishing the formation of scar tissue and the capsule ( Yari-Ilkhchi et al, 2024 ). PVA hydrogel has favorable elastic properties that mitigate the mechanical response exerted on the spinal cord.…”

Section: Application Of Biomaterials Scaffolds In Scimentioning

confidence: 99%

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Gao,

Wang,

et al. 2024

Front. Cell. Neurosci.

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Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory factors, and signaling pathways within the spinal cord. Many biomaterials have been investigated in the treatment of SCI, including hydrogels and fiber scaffolds, and some progress has been made in the treatment of SCI using multiple materials. However, there are limitations when using individual biomaterials in SCI treatment, and these limitations can be significantly improved by combining treatments with stem cells. In order to better understand SCI and to investigate new strategies for its treatment, several combination therapies that include materials combined with cells, drugs, cytokines, etc. are summarized in the current review.

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Applications of Regenerative Tissue-Engineered Scaffolds for Treatment of Spinal Cord Injury

Bradshaw,

Leipzig

2024

Tissue Engineering Part A

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Design and synthesis of nano-biomaterials based on graphene and local delivery of cerebrolysin into the injured spinal cord of mice, promising neural restoration

Abstract: Spinal cord injury (SCI) is an incurable and catastrophic health issue with no clinical solution. As part of cascade reactions, the inflammatory process and fibrous glial scar production aggravate the...

Cited by 5 publications

References 63 publications

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Applications of Regenerative Tissue-Engineered Scaffolds for Treatment of Spinal Cord Injury

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