Design and synthesis of novel 1,3,4‐oxadiazole based azaspirocycles catalyzed by NaI under mild condition and evaluated their antidiabetic and antibacterial activities

Abstract

A modest, efficient, and mild synthetic procedure has been developed for the synthesis of novel series of 1,3,4‐oxadiazole containing azaspirocycles derivatives. The reaction of 1,3,4‐oxadiazole derivative with diverse azaspiro compounds under room temperature condition with helps of sodium iodide catalyst and polar aprotic solvent. Numerous compensations of this strategy embrace less time required, yield increment, consumption of all reactants, and mild condition. All synthesized compounds evaluated for in vitro antidiabetic and antibacterial screening. Among them some compounds show significant biological response.

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

“…151 Some therapeutic agents are used to cure DM, classified as α-glycosidase inhibitors, thiazolidinediones, 5,152 biguanides, 153 sulfonylureas, 154 and gliptins. 155 Deazaxanthine 156 and also various heterocyclic synthetic based pyrrole, 157 pyrazole, 158 pyrrolidine, 159 oxindole, 160 isatin, 161 imidazole, 162 benzimidazole, 163 triazole, 164 oxadiazole, 165 thiazole, 166 pyridine, 167 piperazine, 168 thiazolidinone, thiadiazole, 169 benzofuran, 170 benzoxazole, 171 coumarin, 172 flavone, 173 piperidine, 174 xanthone 175 and pyrimidine. 176 The core structures of antidiabetic moieties are given in Fig.…”

Microwave-assisted synthesis of bioactive tetrahydropyrimidine derivatives as antidiabetic agents

“…Heterocyclic moieties have been broadly employed in the synthesis of pharmacologically active entities. [1,2] Specifically, pyrimidine and fused pyrimidine-based entities play a key role in the field of drug discovery. Currently, much consideration has been paid to pyrimidine derivatives due to their biological activity and therapeutical potential.…”

Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents

“…An increase in the lipophilic chain is a key factor to improve the bioavailability of molecules in the body protein. Mainly our focus and contribution to medicinal chemistry are to design and develop antidiabetic, anticancer, antioxidant, and antimicrobial agents [14][15][16][17][18][19][20][21].…”