Design and synthesis of novel fused heterocycles using 4-chromanone as synthon

Crystal structure of 1,4-dihydro-1-phenylchromeno[4,3-c]pyrazole, C16H12N2O

“…In our previous work, we report the synthesis and pharmacological activities of some other nitrogen-based heterocyclic derivatives as analgesic and anti-in ammatory [5][6][7], SARS-CoV 3C-like protease inhibitors [8], monoamino oxidase inhibitors [9], anticancer [10,11], and antimicrobial [12] agents. Recently, a series of azole, azolopyrimidine, and pyridopyrimidine derivatives containing chromanone moieties were reported [13]. The asymmetric unit of the title compound of the title compound contains one molecule.…”

“…To a solution of (E)-3-((dimethylamino)methylene)-2,3-dihydrochromen-4-one (0.2 g, 1 mmol) in glacial acetic acid (10 mL) was added the phenyl hydrazine (1 mmol [13].…”

Chromanone-A Prerogative Therapeutic Scaffold: An Overview

“…For treatment of inflammation, diverse range of isolated homoisoflavanones, dihydroflavonols such as dihydromyricetin, hesperitin, stilbin and silybin containing chromanone pharmacophore are reported with vivid bioactivity and play an exclusive role in discovery and development of new anti-inflammatory drugs [ 60 ]. Among the isolated compounds from natural sources, chroman-4-one containing stilbin and silybin are used clinically as anti-inflammatory drugs.…”

“…Generally, SAR studies revealed that C-2 substitution with hydroxybenzylidine, arylidene, hydroxyphenyl, pyridine-3-yl and fluorophenyl displayed the best anti-inflammatory activity with significant inhibition. So, exploring the substitutions at C-3, 6, 7 and 8th of chromanone nucleus yields more efficient anti-inflammatory compounds which can compete isolated phytochemicals as well as existing anti-inflammatory drugs [ 60 , 62 ]…”

Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: a novel series of potent antimicrobial and anticancer agents

“…In particular, chromene compounds are well known as important components either in biologically active synthetic or natural compounds (Devakaram et al, 2012[ 16 ]; Iriti and Faoro, 2010[ 26 ]; Juan et al, 2001[ 29 ]; Ren et al, 2011[ 48 ]). Certain natural and synthetic chromene analogues have shown a diversity of interesting properties over the years (Ali et al, 2015[ 5 ]; Cai et al, 2006[ 11 ]; Cheng et al, 2003[ 14 ]; Jain et al, 2009[ 28 ]; Kamdar et al, 2010[ 30 ]; Kemnitzer et al, 2008[ 31 ]; Mladenovic et al, 2011[ 40 ]; Mori et al, 2006[ 41 ]; Thareja et al, 2010[ 60 ]). Some of these molecules exhibited significant effects as antitumor (Cai et al, 2006[ 11 ]; Kemnitzer et al, 2008[ 31 ]), antivascular (Gourdeau et al, 2004[ 23 ]), antimicrobial (Ali et al, 2015[ 5 ]), antioxidant (Mladenovic et al, 2011[ 40 ]), antifungal (Thareja et al, 2010[ 60 ]), anticoagulant (Jain et al, 2009[ 28 ]), anti-HIV (Park et al, 2008[ 45 ]) and anti-inflammatory (Kamdar et al, 2010[ 30 ]) activities.…”