Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds

Design, synthesis and anticancer activity of Michael-type thiol adducts of α-santonin analogue with exocyclic methylene

“…21 α-Santonin derivatives have also been reported to possess anti-inflammatory activity mainly by targeting the NF-κB signalling pathway. 26 As part of our continued interest in the design and synthesis of sesquiterpene lactone based anticancer agents, 21,27 we here report the synthesis and anticancer activity of Micheal typethiol adducts of α-santonin. Michael adducts were synthesized through reaction of a series of aromatic, aliphatic, cyclic and heterocyclic thiols with the α-methylene group generated on the lactone ring of santonin.…”

What Has Come out from Phytomedicines and Herbal Edibles for the Treatment of Cancer?

“…Novel coronopilin derivatives were prepared by incorporating the substituted 1,2,3‐triazole moiety at the β‐position of the cyclopentenone ring in parthenin via CuAAC reaction. Among these derivatives, chlorobenzoyl‐substituted triazole 3 a exhibited anticancer activity on prostate cancer cells and significant inhibition of the NF‐κB pathway (p65) (Figure ) …”

Design, synthesis, and anticancer evaluation of acetamide and hydrazine analogues of pyrimidine

“…Because of the wide clinical applications, interest in pyrimidine derivatives has led to the preparation and evaluation of hundreds of such type of molecules as potent anticancer agents revealing that pyrimidine is an important pharmacophore in the discovery of novel active molecules. In view of the above facts and in continuation of our previous efforts in the field of synthesis of novel anticancer therapeutics, the target in this study was to synthesize analogues having pyrimidine moiety conjugated through acetamide and hydrazinyl linkage with different aromatic/heterocyclic groups of documented cytotoxic potency against several cancer cell lines.…”