Design and synthesis of novel phthalocyanines as potential antioxidant and antitumor agents starting with new synthesized phthalonitrile derivatives

Abstract

New phthalonitrile derivatives formed from reactions of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) were considered as the key intermediates for the synthesis of new phthalocyanines.

Co (II), Ni (II), and Cu (II) ternary complexes with 2,6‐pyridinedicarboxylic acid: Thermal decomposition, DNA interaction, and biological activity studies

“…Cleavage activity is determined by examining the capability of the complex to modify the SC‐DNA to a nicked or linear form. When SC‐DNA is subjected to photolytic cleavage, a relatively fast moment is seen in the intact SC‐DNA, a slow moment is observed for the open circular form, and a linear form is obtained when both helices are cleaved, which migrates in between the SC‐DNA form and the nicked form 41,42 . Results from the current study (Figure 9) show that while nicked form and linear form were rising, proportionately supercoiled DNA form continuously declined 43 .…”

“…When SC-DNA is subjected to photolytic cleavage, a relatively fast moment is seen in the intact SC-DNA, a slow moment is observed for the open circular form, and a linear form is obtained when both helices are cleaved, which migrates in between the SC-DNA form and the nicked form. 41,42 Results from the current study (Figure 9) show that while nicked form and linear form were rising, proportionately supercoiled DNA form continuously declined. 43 Further, it has been found that all complexes (1-3) more effectively encourage the cleavage of pBR322's supercoiled DNA.…”

Design of N-heterocycle based-phthalonitrile/metal phthalocyanine–silver nanoconjugates for cancer therapies

“…Additionally, there were differences between the proliferative properties of Wl38 dark and light groups since the normal healthy cell line could respond to chemical compounds differently. 62–68 Therefore, some of the studied nanoconjugates exhibited high photocytotoxicity against the WI38 cell line. However, the cancer cells were affected by the studied irradiated/non-irradiated drug candidates approximately in a similar manner (darkness and light group).…”

“…Additionally, there were differences between the proliferative properties of Wl38 dark and light groups since the normal healthy cell line could respond to chemical compounds differently. [62][63][64][65][66][67][68] Fig. 3 The process of cancer formation and the predicted effect of nanoconjugates (1-4-AgNPs).…”

Copper(II) Complexes Derived from Schiff Bases Containing 4‐Methylbenzylamine as a Core Unit: Cytotoxicity, pBR322‐DNA Studies, Biological Assays, and Quantum Chemical Parameters

“…Molecular oxygen or diffusible hydroxyl radicals, both of which are capable of damaging DNA by Haber-Weiss type chemistry, [36,37] when copper ions interact with H 2 O 2 in an oxidative cleavage process, leading to the cleavage of SC pBR322 DNA. DNA cleavage occurs as a result of 1 O 2 critical role in the photolytic cleavage pathway.…”