Design and synthesis of some new pyrazolyl-pyrazolines as potential anti-inflammatory, analgesic and antibacterial agents

Crystal structure of 5-(2-chloro-5-nitrophenyl)-3-(4-chlorophenyl)-N-ethyl-4,5-dihydro-1H-pyrazole-1-carbothioamide, C18H16Cl2N4O2S

“…They have signi cant biological activities including antimicrobial, anticonvulsant and antiviral [5][6][7][8][9]. The asymmetric unit of the title structure contains one molecule, in which the phenyl ring (C10-C15) is highly deviated from the whole molecule plane and makes a dihedral angle of 78.74(3)°with the pyrazol ring (N1-N2-C7-C8-C9).…”

Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives

“…NSAIDs suppress the production of prostaglandins (PGs), which is a main precursor for the biosynthesis of many inflammatory mediators, which stimulates inflammatory reactions in the body [4]. These drugs block the arachidonic acid metabolism via inhibition of several enzymes involved in the synthesis of PGs.…”

“…oxiran-2-ylmethoxy)-2H-chromen-2-one (5) was synthesized by reacting 7-hydroxy-4-methyl-2H-chromen-2-one (3) with excess of epichlorohydrin(4) in presence of K 2 CO 3 under reflux conditions. 7-(3-Chloro-2-hydroxypropoxy)-4-methyl-2H-chromen-2-one (5a) was obtained as a side product in low yield in the synthesis of compounds.…”

Design, synthesis, and pharmacological studies of some new Mannich bases and S-alkylated analogs of pyrazole integrated 1,3,4-oxadiazole

“…Modification of molecular structure can be a productive source for new biologically active molecules. Motivated by the aforementioned findings and as a continuation of our work on pyrazole chemistry [31,32,41], we intend to investigate synthesis of a new series of hybrid compounds having pyrazole bridged to the biologically active scaffold 1,3,4-oxadiazole, along with their Mannich bases and S-alkylated products. These new series of compounds have been synthesized with the hope that the hybridization of different molecules will result in a synergistic effect on their antiinflammatory, analgesic, and antimicrobial activities.…”