Design and synthesis of some thieno[2,3-c]pyridazine derivatives of expected anticancer activity

Drugs Against Neurodegenerative Diseases: Design and Synthesis of 6‐Amino–substituted Imidazo[1,2‐b]pyridazines as Acetylcholinesterase Inhibitors

“…Hetrocyclic ring nucleus with a bridgehead nitrogen atom bearing extra two nitrogen atoms such as, imidazo[1,2‐b] pyridazines, have emerged as a important pharmacophore of immense biological importance. These compounds have been found to be a new chemical entity exhibiting broad spectrum of biological activities viz., analgesic, anti‐inflammatory and antitumor activities, human picornavirus, macrofilaricidal activity, a potent inhibitor of acyclin‐dependent kinase, as a ligand for β‐amyloid plaques, IKKβ inhibitors, as novel VEGFR2 kinase inhibitors, antiproliferative activity, AchE inhibitory effects, anticancer, antiviral, antioxidant, anti‐inflammatory, antimicrobial and antiparkinsonian properties …”

SABRE hyperpolarized anticancer agents for use in 1H MRI

“…Pyridazine chemistry is a major research interest because its derivatives exhibit a wide variety of biological roles that include anti‐inflammatory, 29,30 anticancer, 31,32 antiviral, 33 and antimicrobial 34 activity. Specifically, the TP motif is found in drugs that demonstrate anticancer activity (e.g., T[2,3‐ d ]P is found in IκB kinase [IKKs] inhibitors 35‐37 …”

Synthesis, Surface, and Antimicrobial Activity of Hydrophobically Thiadiazole, Pyridazine, and Pyrimidine Systems Based on Surface Active Agents

“…Moreover, there has been growing interest in the synthesis of biologically active pyridazine derivatives in the last decade . Furthermore, many organic compounds containing pyrimidine nuclei are highly efficient towards various microorganisms such as anti‐inflammatory and antimicrobial activities , where a number of pyridazine derivatives have interesting pharmacological and anticancer activities . On the other hand, many fats and oils are used to produce customized products, which are useful for synthesis of environmentally friendly and new compounds .…”