Design and Synthesis of Spirocycles

Kotha, Sambasivarao; Panguluri, Nageswara Rao; Ali, Rashid

doi:10.1002/ejoc.201700439

Cited by 116 publications

(55 citation statements)

References 141 publications

(59 reference statements)

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“…A pericyclic [4+2]‐cycloaddition protocol is a powerful tool and has been continuously used by the synthetic organic chemists for the generation of diverse medicinally active molecules. Since its finding in 1928 (Nobel Prize 1950) in the laboratory of Otto Diels, its applications in organic synthesis is growing exponentially day‐by‐day, and to my best knowledge almost every architecturally complex natural or non‐natural products involve this powerful tool at some stage to showcase the target molecules . In this context, a variety of dienes and dienophiles either commercially available or easily prepared have been employed in DA‐reaction .…”

Section: Applications Of Rongalite Chemistry In Organic Synthesismentioning

confidence: 99%

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

Ali

2020

ChemistrySelect

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Rongalite, first time reported in the chemical structure in 1905, also known as bruggolite or sodium formaldehyde sulfoxylate, having good solubility and stability in organic media, is not only a cheap and commercially available (in kg amount) reagent with a range of industrial applications for instance emulsion polymerization, an excellent decolouring agent, antioxidant in pharmaceutical development, and an antidote for heavy metals, but also used as an effective regents in a plethora of organic reactions particularly in redox reactions as a powerful reducing agent. More interestingly, in recent years, it has also shown its impact in material sciences for the preparation of CdTe, CoTe2, and Ag2Se thin films, nanowire networks, hollow nanospheres, copper nanoparticles (Cu‐Nps), CdTe‐quantum dots and so forth. Keeping in mind the importance of this vital reagent in both organic chemistry as well as in material sciences, herein I intended to report the recent developments along with a brief overview of old literature wherever necessary to showcase the utility of this valuable reagent. This particular review article not only covers the applications of this environmentaly benign reagent in organic synthesis but also its usefulness in material sciences in particular nanosciences has been exposed for the first time.

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Section: Applications Of Rongalite Chemistry In Organic Synthesismentioning

confidence: 99%

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

Ali

2020

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“…They not only play momentus role in optoelectronics, displays and silver free imaging systems but also in bioactive naturals and non‐natural compounds. Keeping this in mind, spirotruxene derivatives 54 a‐f along with their photophysical properties have been reported by Kotha and his coworkers using cyclotrimerization, ring‐closing metathesis and Suzuki‐Miyaura cross‐coupling reactions as key transformations (scheme ) …”

Section: Some Selected Recent Approaches Towards the Synthesis Of Trumentioning

confidence: 99%

Functionalized Truxene Scaffold: A Promising Advanced Organic Material for Digital Era

2019

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Truxene and its congeners due to its structural, thermal, and optoelectronic properties, has recently became important not only in biological systems but also in the field of material and environmental sciences. The remarkable scope and its applicability ranging from sensory materials to photocatalysts and fluorescent probes, forces the scientific community to think about the design and construction of architecturally simple yet much powerful novel functional materials possessing the truxene scaffold(s) in their structures. Herein, we have focused to assemble a series of ground‐breaking achievements in recent years of truxene‐based functional materials with special emphasis on their applicability in material sciences and technology. We hope that the present review will boost the current scenario of truxene and its various domains.

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“…In 2009, we have demonstrated the synthesis of highly substituted diphenylalkane derivatives via CEM under ethylene followed by the DA reaction and subsequent aromatization sequence. [74] The strategy involves a step-wise functionalization of acetylene moiety, where initial CEM with ethylene in the presence of the G-II catalyst generated the required diene. Then, the resulting diene was subjected to DA reaction followed by aromatization to yield highly functionalized aromatic frameworks.…”

Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

Development of New Synthetic Strategies, Tactics and their Applications

Kotha

Meshram

2019

The Chemical Record

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This account covers our work related to the development of various synthetic methodologies since 1994. We summarized our strategies and their application to design various functional molecules. In this regard, we also report the utility of our methodologies in others research work. These methods we report here are simple and efficient for the synthesis of a wide variety of intricate molecules such as heterocycles, polycycles, unusual α‐amino acids, star‐shaped molecules, and modified peptides. For this purpose, we used various transition metal‐based reagents and catalysts. Various popular reactions such as metathesis, Suzuki coupling, [2+2+2] cyclotrimerization were used to assemble these targets. Moreover, rongalite has been used to expand the Diels‐Alder chemistry.

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Design and Synthesis of Spirocycles

Cited by 116 publications

References 141 publications

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

Functionalized Truxene Scaffold: A Promising Advanced Organic Material for Digital Era

Development of New Synthetic Strategies, Tactics and their Applications

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