Design and synthesis of triazole Schiff bases and their oxovanadium(IV) complexes as antimicrobial agents

Crystal structure of 2-[(2-bromophenylimino)methyl]-4-chlorophenol, C13H9BrClNO

“…They have demonstrated significant biological activities, e. g., antimicrobial [1], antitumour and antiviral activities [2][3][4]. The title crystal structure is built up only by the Schiff base molecules, within which all bond lengths and bond angles are in normalranges [5].…”

Design, synthesis andin vitrobactericidal/fungicidal screening of some vanadyl(IV)complexes with mono- and di-substituted ONS donor triazoles

“…Orally active medication of these compounds as drug represents an important advancement in the curative approach of human diabetes mellitus. Other potential applications of vanadyl complexes have also been studied in promoting the biological activities such as anti-bacterial 17 , anti-fungal 18 , spermicidal 19 , anti-tumor 20 , anti-leukemic 21 and anti-amoebic 22 activity. Due to increased interest in bioactive potentials of triazoles and vanadium metal, it was thought valuable to combine both the chemistry of triazoles and vanadium metal to form a novel class of vanadium metal based triazoles that could serve as probable bactericidal and fungicidal against resistant bacterial/fungal strains.…”

Computational POM and DFT Evaluation of Experimental in-vitro Cancer Inhibition of Staurosporine-Ruthenium(II) Complexes: The Power Force of Organometallics in Drug Design

“…A suitable theoretical concept is that proposed by Ben Hadda et al [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] apropos of definition of pharmacophore site. The best descriptors for studying and identifying the type of pharmacophore site (antibacterial, antiviral or antitumor) are the description in detail of local electrophilicity and the nucleophilicity of each functionalized group and their spatial arrangement.…”

“…[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] For these reasons, we constructed a platform of some of the key bioinformatic model in order to predict and characterize the antitumor drugs performance of the tested series of staurosporine-ruthenium(II) complexes. Our aim in this work is to give a deeper insight into the coordination effect of transition metal (ruthenium) to bioactive drug (staurosporine), on the inhibition efficiency of ruthenium-staurosporine complexes ( Figure 1) using POM and DFT analyses.…”

“…[9][10][11][12][13][14][15][16][17][18][19][20][21][22] Recently, it has been shown that the kinase inhibition by an organometallic systems under biological condition may be significantly facilitated if a ligand containing an anti-kinase pharmacophore (NH-C=O), a bidentate N,N coordinative site (staurosporine derivatives) and non-toxic metal (ruthenium) are available. [2][3][4][5][6] The cancer inhibition of kinase enzymes through organic drugs has been the subject of different theoretical investigations.…”