Design and translation of injectable biomaterials

Nguyen, Michael; Karkanitsa, Maria; Christman, Karen L.

doi:10.1038/s44222-024-00213-1

Nat Rev Bioeng

2024

DOI: 10.1038/s44222-024-00213-1

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Design and translation of injectable biomaterials

Michael Nguyen,

Maria Karkanitsa,

Karen L. Christman

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2024

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Cited by 2 publications

References 241 publications

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Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

Xiao,

Dai,

et al. 2024

Adv Funct Materials

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Photothermal hydrogels (PTHs) are considered next‐generation biomaterials as they offer remotely defined biophysical information of the extracellular milieu. PTHs allow precise and non‐genetic control for the regeneration of native tissues, which is the ultimate goal of tissue engineering (TE). Molecular and physical properties of PTHs, such as components, structural configurations, and mechanical characteristics, collectively serve as determinants for understanding the dynamic tissue response and clinical translation. PTHs have entered a period of fruition due to the development of numerous manufacturing technologies and polymeric matrices. Herein, this review comprehensively and meticulously elucidates the mechanisms of regenerative therapeutics underlying the design and fabrication of PTHs. Recent advances in the photothermal principles and various categories of photothermal agents (PTAs) have been extensively discussed. Vital components and structures of PTHs are summarized to enable efficacious and precise therapeutic energy delivery. Emerging applications of PTHs in TE are also demonstrated, which expand the strategies for the intrinsic regeneration of injured tissues. Then deliberate the structural and chemical engineering of PTHs to enhance prognosis while highlighting the challenges associated with clinical translation. In this review, we aim to provide guidance and prospects for exploration and innovation of PTHs in the field of TE.

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Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

Xiao,

Dai,

et al. 2024

Adv Funct Materials

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Prolonging Endothelial Cell Survival with Thermoresponsive Peptide‐Functionalized Hydrogels Improves Ischemic Limb Tissue Regeneration and Function

Wang,

Dang,

Rivera‐Bolanos

et al. 2024

Adv Funct Materials

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Critical limb ischemia (CLI) presents a significant clinical challenge, leading to tissue ischemia and potentially resulting in limb necrosis or amputation. Cell‐based regenerative therapies offer promise for improving outcomes in CLI, but their effectiveness is often limited by poor cell survival and engraftment. This study hypothesized that a thermo‐responsive polymer, poly(polyethylene glycol citrate‐co‐N‐isopropylacrylamide) (PPCN), combined with pro‐survival bioactive peptides, can create a protective microenvironment to improve endothelial cell survival and function after their delivery. Through in vitro and in vivo experiments, laminin‐derived peptide A5G81 and vascular endothelial growth factor (VEGF)‐derived peptide QK are identified as effective in promoting endothelial cell spreading, proliferation, and prolonged survival. PPCN's viscoelastic properties protected against shear stress during injection, while the peptides supported endothelial cell behavior through distinct molecular pathways. Importantly, delivery of endothelial cells with PPCN‐A5G81 and PPCN‐QK in a murine hindlimb ischemia model resulted in significant improvements in limb perfusion, tissue preservation, and functional outcomes compared to controls. Additionally, this approach enhanced skeletal muscle remodeling following ischemic injury. This innovative biomaterial platform represents a versatile solution for addressing cell survival challenges and advancing regenerative therapies in CLI and other ischemic conditions.

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Design and translation of injectable biomaterials

Cited by 2 publications

References 241 publications

Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

Prolonging Endothelial Cell Survival with Thermoresponsive Peptide‐Functionalized Hydrogels Improves Ischemic Limb Tissue Regeneration and Function

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