Design, characterization, and modeling of a chitosan microneedle patch for transdermal delivery of meloxicam as a pain management strategy for use in cattle

Castilla‐Casadiego, David A.; Carlton, Hayden; Gonzalez-Nino, David; Miranda-Muñoz, Katherine A.; Daneshpour, Raheleh; Huitink, David; Prinz, Gary S.; Powell, J. G.; Greenlee, Lauren F.; Almodóvar, Jorge

doi:10.1016/j.msec.2020.111544

Cited by 59 publications

(50 citation statements)

References 33 publications

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“…Prepared patches have a highly porous morphology ( Figure 5 , Figure 6 and Figure 7 ) and hydrophilic groups in their structure thanks to their modification with amino acids ( Figure 2 ). In general, it is known that hydrogels are superior to other polymeric materials in diffusion-controlled drug delivery systems [ 17 , 25 , 26 , 27 , 30 , 37 , 39 , 40 ]. They have a great affinity to aquatic solution.…”

Section: Resultsmentioning

confidence: 99%

“…Appropriate morphology of the material used as a potential transdermal patch is crucial for several reasons. The structure should be highly porous [25][26][27]37]. Importantly, there are many bioinert and biocompatible polymeric devices which could be potentially applied for drug delivery, but because of their very low porosity or even solid character Zinc oxide nanoparticles are known to be semiconductors and can conduct current.…”

Section: Morphology Studymentioning

confidence: 99%

“…The term hydrogel in this case refers to the 3D, highly porous structure which can be swollen with aquatic medium. 27,30,37,39,40]. They have a great affinity to aquatic solution.…”

Section: Swelling Abilities Studymentioning

confidence: 99%

“…Chitosan is widely applied in medicine and pharmacy as wound dressings, drug delivery systems, scaffolds, or hemostatic agents. It is also used in wastewater treatment or catalysis [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. CS-based transdermal systems can be in various forms such as nanoparticles, microspheres, or membranes.…”

Section: Introductionmentioning

confidence: 99%

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Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery

et al. 2021

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One of the most common neurological diseases is epilepsy, which not only negatively affects the quality of people’s life but also may lead to life-threatening situations when its symptoms such as seizures cannot be controlled medically. A very serious problem to be overcame is the untreatable form of this disease, which cannot be cured by any currently available medicines. Cannabidiol, which is a natural product obtained from Cannabis Sativa, brings a new hope to people suffering from drug-resistant epilepsy. However, the hydrophobic character of this compound significantly lowers its clinical efficiency. One of the promising methods of this substance bioactivity increase is delivery through the skin tissue. In this article, a new type of advanced transdermal systems based on chitosan and ZnO nanoparticles (NPs) has been developed according to Sustained Development principles. The chemical modification of the biopolymer confirmed by FT-IR method resulted in the preparation of the material with great swelling abilities and appropriate water vapor permeability. Obtained nanoparticles were investigated over their crystalline structure and morphology and their positive impact on drug loading capacity and cannabidiol controlled release was proved. The novel biomaterials were confirmed to have conductive properties and not be cytotoxic to L929 mouse fibroblasts.

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Section: Resultsmentioning

confidence: 99%

Section: Morphology Studymentioning

confidence: 99%

“…The term hydrogel in this case refers to the 3D, highly porous structure which can be swollen with aquatic medium. 27,30,37,39,40]. They have a great affinity to aquatic solution.…”

Section: Swelling Abilities Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery

et al. 2021

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“…Computational methods that allow for simulation of the experiment or setup conditions for prognosticating their behaviors with conceivable problems or using artificial intelligence techniques for post analysis of data [25] have also emerged in MNs. Finite element analysis was used for simulating the transdermal drug delivery process of MNs into the skin in order to study the effect of penetration depth and number of MNs on each patch, demonstrating increasing proportionality of delivered drugs with both factors [26].…”

Section: Introductionmentioning

confidence: 99%

Finger-Actuated Microneedle Array for Sampling Body Fluids

2021

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The application of microneedles (MNs) for minimally invasive biological fluid sampling is rapidly emerging, offering a user-friendly approach with decreased insertion pain and less harm to the tissues compared to conventional needles. Here, a finger-powered microneedle array (MNA) integrated with a microfluidic chip was conceptualized to extract body fluid samples. Actuated by finger pressure, the microfluidic device enables an efficient approach for the user to collect their own body fluids in a simple and fast manner without the requirement for a healthcare worker. The processes for extracting human blood and interstitial fluid (ISF) from the body and the flow across the device, estimating the amount of the extracted fluid, were simulated. The design in this work can be utilized for the minimally invasive personalized medical equipment offering a simple usage procedure.

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Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics

Wang,

Xiao,

et al. 2024

Adv Healthcare Materials

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Wearable epidermal electronics with non‐ or minimally‐invasive characteristics can collect, transduce, communicate, and interact with accessible physicochemical health indicators on the skin. However, due to the stratum corneum layer, rich information about body health is buried under the skin stratum corneum layer, e.g., in the skin interstitial fluid. Microneedle patches are typically designed with arrays of special microsized needles of length within 1000 μm. Such characteristics potentially enable the access and sample of biomolecules under skin or give therapeutical treatment painlessly and transdermally. Integrating microneedle patches with various electronics allows highly efficient transdermal bioelectronics, showing their great promise for biomedical and healthcare applications. This comprehensive review summarizes and highlights the recent progress on integrated transdermal bioelectronics based on microneedle patches. The design criteria and state‐of‐the‐art fabrication techniques for such devices are initially discussed. Next, devices with different functions, including but not limited to health monitoring, drug delivery, and therapeutical treatment, are highlighted in detail. Finally, key issues associated with current technologies and future opportunities are elaborated to sort out the state of recent research, point out potential bottlenecks, and provide future research directions.This article is protected by copyright. All rights reserved

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Design, characterization, and modeling of a chitosan microneedle patch for transdermal delivery of meloxicam as a pain management strategy for use in cattle

Cited by 59 publications

References 33 publications

Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery

Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery

Finger-Actuated Microneedle Array for Sampling Body Fluids

Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics

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