Design, clinical applications and post-surgical assessment of bioresorbable 3D-printed craniofacial composite implants

Targońska, Sara; Dobrzyńska-Mizera, Monika; Di Lorenzo, Maria Laura; Knitter, Monika; Longo, Alessandra; Dobrzyński, Maciej; Rutkowska, Monika; Barnaś, Szczepan; Czapiga, Bogdan; Stagraczyński, Maciej; Mikulski, Michał; Muzalewska, Małgorzata; Wyleżoł, Marek; Rewak-Soroczyńska, Justyna; Nowak, Nicole; Andrzejewski, Jacek; Reeks, John; Wiglusz, Rafal J.

doi:10.1039/d3bm01826a

Biomater. Sci.

2024

DOI: 10.1039/d3bm01826a

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Design, clinical applications and post-surgical assessment of bioresorbable 3D-printed craniofacial composite implants

Sara Targońska,

Monika Dobrzyńska-Mizera,

Maria Laura Di Lorenzo

et al.

Abstract: This study details the design, fabrication, clinical trials’ evaluation, and analysis after the clinical application of 3D-printed bone reconstruction implants made of nHAp@PLDLLA [nanohydroxyapatite; poly(L-lactide-co-D,L-lactide)] biomaterial. The 3D-printed formulations have...

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Cited by 3 publications

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Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

Dobrzyńska‐Mizera,

Dodda,

Liu

et al. 2024

Adv Healthcare Materials

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Herein, the recent advances in the development of resorbable polymeric‐based biomaterials, their geometrical forms, resorption mechanisms, and their capabilities in various biomedical applications are critically reviewed. A comprehensive discussion of the engineering approaches for the fabrication of polymeric resorbable scaffolds for tissue engineering, drug delivery, surgical, cardiological, aesthetical, dental and cardiovascular applications, are also explained. Furthermore, to understand the internal structures of resorbable scaffolds, representative studies of their evaluation by medical imaging techniques, e.g., cardiac computer tomography, are succinctly highlighted. This approach provides crucial clinical insights which help to improve the materials’ suitable and viable characteristics for them to meet the highly restrictive medical requirements. Finally, the aspects of the legal regulations and the associated challenges in translating research into desirable clinical and marketable materials of polymeric‐based formulations, are presented.

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Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

Dobrzyńska‐Mizera,

Dodda,

Liu

et al. 2024

Adv Healthcare Materials

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show abstract

Advancements in 3D printing of functional materials for biomedical applications: challenges, opportunities, and case studies: a critical review

Goyal,

Verma,

Saxena

2024

Prog Addit Manuf

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Thermosensitive hydrogel doped with osteoconductive fillers for the treatment of periodontitis periapicalis chronica: from synthesis to clinical trial

Dobrzyńska-Mizera,

Knitter,

Kamińska

et al. 2024

Biomater. Sci.

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Design, clinical applications and post-surgical assessment of bioresorbable 3D-printed craniofacial composite implants

Abstract: This study details the design, fabrication, clinical trials’ evaluation, and analysis after the clinical application of 3D-printed bone reconstruction implants made of nHAp@PLDLLA [nanohydroxyapatite; poly(L-lactide-co-D,L-lactide)] biomaterial. The 3D-printed formulations have...

Cited by 3 publications

References 58 publications

Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

Advancements in 3D printing of functional materials for biomedical applications: challenges, opportunities, and case studies: a critical review

Thermosensitive hydrogel doped with osteoconductive fillers for the treatment of periodontitis periapicalis chronica: from synthesis to clinical trial

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