Abstract:BackgroundThe E2 glycoprotein is an important encoded hepatitis C virus (HCV) protein that contains three different variable regions.ObjectivesThe aim of the present study was to construct an HCV 1a/JFH1 chimeric virus by replacing the intergenotypic variable region (igVR) fragment of the highly variable region of the E2 gene of the Japanese Fulminant hepatitis genotype 2a JFH1 virus with a similar region of HCV genotype 1a. This chimera was produced as a model virus with the ability to be cultured. We analyze… Show more
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