Design, construction and testing of a monolithic pH-sensitive hydrogel-valve for biochemical and medical application

Ayala, Virginia C; Michalzik, Monika; Harling, Steffen; Menzel, Henning; Guarnieri, Fabio Ariel; Büttgenbach, S.

doi:10.1088/1742-6596/90/1/012025

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…They further functionalized the octopus with a glucose‐responsive eye by using horseradish peroxidase and glucose oxidase which endowed biochemical responsivity . There are other examples of biomimetic structures based on temperature, magnetic fields, pH, biochemical reactions and ionic concentration …”

Section: Applicationsmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

240

211

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Hydrogels, which are hydrophilic soft porous networks, are an important class of materials of broad relevance to bioanalytical chemistry, soft‐robotics, drug delivery, and regenerative medicine. Transformer hydrogels are micro‐ and mesostructured hydrogels that display a dramatic transformation of shape, form, or dimension with associated changes in function, due to engineered local variations such as in swelling or stiffness, in response to external controls or environmental stimuli. This review describes principles that can be utilized to fabricate transformer hydrogels such as by layering, patterning, or generating anisotropy, and gradients. Transformer hydrogels are classified based on their responsivity to different stimuli such as temperature, electromagnetic fields, chemicals, and biomolecules. A survey of the current research progress suggests applications of transformer hydrogels in biomimetics, soft robotics, microfluidics, tissue engineering, drug delivery, surgery, and biomedical engineering.

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Section: Applicationsmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

240

211

View full text Add to dashboard Cite

show abstract

“…A polyamide rate-modu-lated monolithic drug delivery system with biocompatible and biodegradable properties was recently patented [21]. A monolithic pH-sensitive hydrogel valve for biochemical and medical applications was designed, constructed and tested in a microfluidic device [22].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible polymeric monoliths for protein and peptide separations

Lee²

2009

J of Separation Science

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The concept of biocompatibility with reference to chromatographic stationary phases for separation of biomolecules (including proteins and peptides) is introduced. Biocompatible is a characteristic that indicates resistance to nonspecific adsorption of biomolecules and preservation of their structures and biochemical functions. Two types of biocompatible polymeric monoliths [i. e., polyacrylamide- and poly(meth)acrylate-based monoliths] used for protein and peptide separations are reviewed in detail, with emphasis on size exclusion, ion exchange, and hydrophobic interaction chromatographic modes. Biocompatible monoliths for enzyme reactors are also included. The two main synthetic approaches to produce biocompatible monoliths are summarized, i. e., surface modification of a monolith that is not inherently biocompatible and direct copolymerization of hydrophilic monomers to form a biocompatible monolith directly. Integration of polyethylene glycol into the poly(meth)acrylate monolith network is becoming popular for reduction of non-specific protein interactions.

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“…They combine multiple sensing and actuation functions in a single component, and regulate the flow by expanding or contracting to seal or open the channel 7–12. In contrast to typical conventional microfluidic actuators ( e.g ., electromagnetic, piezoelectric or thermopneumatic), stimuli‐responsive hydrogels can be integrated as a microfluidic component ( e.g ., microvalves, micropumps) without the need for an external energy supply and complex fabrication schemes 7–12. Thus, an application of stimuli‐responsive hydrogels could significantly reduce the microfluidic system complexity, keeping at the same time their multiple functionalities.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic chip with integrated microvalves based on temperature‐ and pH‐responsive hydrogel thin films

Bäcker

Raue

Schusser

et al. 2012

Physica Status Solidi (a)

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241-6009-53235 y Both the authors contributed equally to this work.Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 8C and different pH values (pH 3-12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature-or pH-responsive microvalve capable to switch the flow channel on/off.

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Design, construction and testing of a monolithic pH-sensitive hydrogel-valve for biochemical and medical application

Cited by 6 publications

References 11 publications

Transformer Hydrogels: A Review

Transformer Hydrogels: A Review

Biocompatible polymeric monoliths for protein and peptide separations

Microfluidic chip with integrated microvalves based on temperature‐ and pH‐responsive hydrogel thin films

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