2022
DOI: 10.1021/acs.oprd.1c00320
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Design, Development, and Analysis of an Automated Sampling Loop for Online Monitoring of Chiral Crystallization

Abstract: Enantiomeric purity is of prime importance for several industries, specifically in the production of pharmaceuticals. Crystallization processes can be used to obtain pure enantiomers in a suitable solid form. However, some process variants inherently rely on kinetic enhancement (preferential crystallization) of the desired enantiomer or on complex interactions of several phenomena (e.g., attrition-enhanced deracemization and Viedma ripening). Thus, a process analytical technology able to measure the enantiomer… Show more

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Cited by 3 publications
(1 citation statement)
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“…While Raman spectroscopy has been extensively studied in research for the mapping or profiling of biological tissues and cells for disease diagnosis and other biomedical applications [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ] or even subcellular analysis [ 39 , 40 , 41 ], it remains a powerful analytical technique. In the field of process analytical technology (PAT), Raman spectroscopy is used to monitor and control chemical and pharmaceutical processes [ 42 , 43 , 44 ], to predict end points of chemical synthesis reactions [ 45 ], and to track polymorphic changes in crystallisation processes [ 46 , 47 ]. Additionally, Raman spectroscopy has been reported as a powerful technique enabling quantitative analysis for a wide range of samples, such as for the determination of water in natural deep eutectic solvents [ 48 , 49 , 50 ], as a quality control tool for chemotherapeutic solutions [ 51 , 52 ], for the quantification of API in solid dosage forms [ 53 , 54 , 55 ], screening human body fluids such as serum [ 56 , 57 ] or for investigating the distribution of AI in complex cosmetic dried films to study their homogeneity [ 58 ].…”
Section: Introductionmentioning
confidence: 99%
“…While Raman spectroscopy has been extensively studied in research for the mapping or profiling of biological tissues and cells for disease diagnosis and other biomedical applications [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ] or even subcellular analysis [ 39 , 40 , 41 ], it remains a powerful analytical technique. In the field of process analytical technology (PAT), Raman spectroscopy is used to monitor and control chemical and pharmaceutical processes [ 42 , 43 , 44 ], to predict end points of chemical synthesis reactions [ 45 ], and to track polymorphic changes in crystallisation processes [ 46 , 47 ]. Additionally, Raman spectroscopy has been reported as a powerful technique enabling quantitative analysis for a wide range of samples, such as for the determination of water in natural deep eutectic solvents [ 48 , 49 , 50 ], as a quality control tool for chemotherapeutic solutions [ 51 , 52 ], for the quantification of API in solid dosage forms [ 53 , 54 , 55 ], screening human body fluids such as serum [ 56 , 57 ] or for investigating the distribution of AI in complex cosmetic dried films to study their homogeneity [ 58 ].…”
Section: Introductionmentioning
confidence: 99%