Design, Development and Evaluation of Mouth Dissolving Tablets of Tofacitinib Citrate

Abstract

Objective: This study aims to Formulate Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate with the increase in bioavailability and patient compliance. Methods: Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate were developed by full factorial design at 32levelsand prepared by direct compression method using super integrants like sodium starch glycolate, Ludiflash. The tablets were compressed into compacts on a 10 station tablet machine. The bulk drug was characterised by determining, MP, Solubility, pH and FTIR spectra. Results: The weight variation, hardness and diameter, thickness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies, and stability study, tablet thickness, weight variation and drug content post compression parameters remained consistent and reproducible. All the formulations showed, almost 100 percent of drug release within 75 min. Formulations F1, F2 and F3 were prepared with 5 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F1<F2<F3. Formulations F4, F5 and F6 were prepared with 10 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F4<F5<F6. Formulations F7, F8 and F9 were prepared with 15 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F7<F8<F9. Conclusion: It is concluded that the amount of superdisintegrants decreases disintegration time of tablets, decreases wetting time, increases the cumulative % drug release causes better absorption.

Lozenges Formulation of Ciplukan (Physalis Angulata L.) Fruit Extract as an Antioxidant With Combination of Filler Agents Avicel Ph 102–ludipress

“…The values of tapped density were found to be between 0.463±0.001 g/ml and 0.636±0.009 g/ml. Tap densities were found within acceptable limit, which indicates that the packing properties required during compression are adequate in all formulations [12].…”

“…The frictional force on the powder can be measured by the angle of repose. It is defined as the maximum possible angle between the surface of the powder pile and the horizontal plane [12]. To determine the Angle of Rest, the powder is passed through a funnel that is aligned vertically, and the height (h) and radius (r) of the pile formed is determined and the angle of rest is calculated using the following formula [13].…”

“…The measuring cup was tapped twice with an interval of 2 seconds using a bulk density apparatus. Bulk density is calculated using the following formula [12].…”

Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs)

“…The notably prolonged dissolution of Ludiflash ® based formulae was attributed to the presence of Kollicoat SR30D, which is used to prepare sustained-release dosage forms. Another work, by Raykar and Velraj, reported tablets containing tofacitinib citrate, Ludiflash ® , and sodium starch glycolate [ 41 ]. Among the nine formulae tested, seven released less than 60% of the drug within 30 min, and only one released the entire dose.…”

Design, Development and Evaluation of Novel Mouth Dissolving Film of Tofacitinib Citrate

“…An oral dose of Tofacitinib citrate bioavailability, Therefore, actual bioavailable dose 3 2 full factorial designs were used for the optimization of the polymer-plasticizer ratio. In this design, 2 factors were evaluated each at 3 levels, and experimental trials were performed in all 9 possible combinations [19]. The amount of polymer HPMC 5 cps (X1) and amount of plasticizer, glycerol (X2) were selected as independent variables and each factor being studied at-1, 0,+1 level.…”