Design, development and method validation of a novel multi-resonance microwave sensor for moisture measurement

Peters, Johanna; Taute, Wolfgang; Bartscher, Kathrin; Döscher, Claas; Höft, Michael; Knöchel, R.; Breitkreutz, Jörg

doi:10.1016/j.aca.2017.01.021

Cited by 33 publications

(6 citation statements)

References 18 publications

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“…Peters et al [106][107][108][109][110] developed a multi resonance microwave sensor, and carried out a series of laboratory and pilot scale-up studies, which could be used in the production of specific drugs (donepezil hydrochloride). Samples with different process parameters were used to establish a satisfactory moisture prediction model.…”

Section: Microwave Resonance Technologymentioning

confidence: 99%

“…The results showed that the sensor can be used as a tool to monitor the moisture contents of particles in the FBG Figure 3 shows the real-time process monitoring of the semi-continuous fluidized bed dryer using MRT and NIRS. Due to the interaction between the water molecules and electromagnetic stray field on the surface of the MRT sensor, MRT is more sensitive to water than NIRS [109] , which makes up for the limited applicability of NIRS in the analysis of the wet granulation process, such as colored particles, and large difference in bulk density [106] .…”

Section: Microwave Resonance Technologymentioning

confidence: 99%

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Granulation process analysis technologies and potential applications in traditional Chinese medicine

Cui

Hou

Feng

et al. 2022

Acupuncture and Herbal Medicine

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Pharmaceutical production is changing from batch production to continuous production, during which granulation is one of the most important unit operations. The quality of mass-produced products is traditionally guaranteed by conducting off-line testing, which cannot meet the demand of continuous production for real-time monitoring of critical process parameters and critical quality attributes (CQAs) of the pharmaceutical granulation technology. Since the U.S. Food and Drug Administration proposed process analytical technology (PAT) in 2004, many PAT tools have been developed to monitor the granulation process and provide information regarding the granulation operation conditions and endpoint determination. In this article, we review the recent research and application of two PAT modes in the granulation process, namely, single CQA and multi-CQA PAT, with the aim to provide references for comprehensively improving the technological level of the pharmaceutical granulation process. Furthermore, the potential applications in traditional Chinese Medicine are discussed.

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Section: Microwave Resonance Technologymentioning

confidence: 99%

Section: Microwave Resonance Technologymentioning

confidence: 99%

Granulation process analysis technologies and potential applications in traditional Chinese medicine

Cui

Hou

Feng

et al. 2022

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

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“…The technology did not yet find its way into pharmaceutical applications to the same extent as the near-infrared (NIR) sensor systems [148][149][150]. However, in contrast to NIR, one benefit of microwave sensors is that microwaves can penetrate orders of magnitude deeper and hence probe a larger sample volume yielding more representative results [151]. For future in-line applications of the microwave sensor in the [127,139], and [129] with permission from IEEE, and from [140] with permission from Taylor & Francis.…”

Section: Application Examplesmentioning

confidence: 99%

“…pharmaceutical world, a thoroughly developed and validated method is crucial, especially as microwave sensors must be calibrated separately for different materials [151]. Furthermore, recent advances and new challenges in microwave tomography systems for industrial process monitoring (particularly real-time monitoring systems) are highlighted in the work of Wu and…”

Section: Application Examplesmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

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“…Microwave sensing technology has been developed over the years for several sensing applications, including liquid solution concentrations [ 26 ], moisture sensors [ 27 ], and real-time glucose monitoring [ 28 ]. Microstrip patch antennas are widely used in sensing applications [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

A Compact Ultrawideband Antenna Based on Hexagonal Split-Ring Resonator for pH Sensor Application

Islam

Ashraf

Alam

et al. 2018

Sensors

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A compact ultrawideband (UWB) antenna based on a hexagonal split-ring resonator (HSRR) is presented in this paper for sensing the pH factor. The modified HSRR is a new concept regarding the conventional square split-ring resonator (SSRR). Two HSRRs are interconnected with a strip line and a split in one HSRR is introduced to increase the electrical length and coupling effect. The presented UWB antenna consists of three unit cells on top of the radiating patch element. This combination of UWB antenna and HSRR gives double-negative characteristics which increase the sensitivity of the UWB antenna for the pH sensor. The proposed ultrawideband antenna metamaterial sensor was designed and fabricated on FR-4 substrate. The electrical length of the proposed metamaterial antenna sensor is 0.238 × 0.194 × 0.016 λ, where λ is the lowest frequency of 3 GHz. The fractional bandwidth and bandwidth dimension ratio were achieved with the metamaterial-inspired antenna as 146.91% and 3183.05, respectively. The operating frequency of this antenna sensor covers the bandwidth of 17 GHz, starting from 3 to 20 GHz with a realized gain of 3.88 dB. The proposed HSRR-based ultrawideband antenna sensor is found to reach high gain and bandwidth while maintaining the smallest electrical size, a highly desired property for pH-sensing applications.

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Design, development and method validation of a novel multi-resonance microwave sensor for moisture measurement

Cited by 33 publications

References 18 publications

Granulation process analysis technologies and potential applications in traditional Chinese medicine

Granulation process analysis technologies and potential applications in traditional Chinese medicine

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

A Compact Ultrawideband Antenna Based on Hexagonal Split-Ring Resonator for pH Sensor Application

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