Design, Development, Formulation, and Evaluation of Gastro retentive Floating Tablet for Anti-diabetic Agent

Abstract

The main aim of the research was to persist the gastric residence time of vildagliptin by designing its gastro-retentive tablet as well as to study the effect of different polymers on its release rate using 23 randomized full factorial designs. Tablets are manufactured by direct compression method. Hydroxypropyl methylcellulose was used as matrixing agent, M.C.C., and Na2Co3 were used. The manufactured tablets assessed for physicochemical parameters such as weight variety, hardness, friability, floating properties (total floating time and floating lag time), in vitro drug release, and drug content, and stability study. The drug- polymer interaction was studied by differential scanning calorimetry and Fourier transform infrared (FTIR). On the basis of preliminary batches, the PF3 batch giving more drug release so that the PF3 batch is used for DoE process. Formulation F7 had been selected as an optimum formulation as it displayed more comparison in dissolution profile with theoretical profile which is 99.89 ± 0.49%. The dissolution of batch F7 can be described by zero order kinetics (R2 = 0.954), First order- R2 = 0.87, Higuchi R2 = 0.989, and Peppa’s R2 = 0.99. Also studied X-ray Photographic Studies in Rabbits and showed tablet was float more than 8 h in gastric region of the Albino rabbits. It could be concluded from this study that the prepared Gastro-retentive tablet could reduce the frequency of dosage, dose related side effects, and increase the bioavailability.