Design, fabrication and testing of a micro-Venturi tube for fluid manipulation in a microfluidic system

Abstract

In this paper, a micro-Venturi tube fabricated with polydimethylsiloxane (PDMS) is studied for interstitial fluid (ISF) transdermal extraction and fluid manipulation in a microfluidic system toward the application of continuous glucose monitoring. The fabrication structure parameters of the PDMS Venturi tube were theoretically analyzed and experimentally validated against the output vacuum efficiency of the Venturi structure. The optimization methods of the Venturi structure were also discussed. In addition, an optimized micro-Venturi structure was proposed and fabricated. A vacuum pressure of less than 86 kPa had been achieved when an external pressure of 240 kPa was applied to this optimized Venturi tube. Both experimental and mathematical results demonstrate the potential applicability of the micro-Venturi tube in ISF transdermal extraction and fluid manipulation.

A continuous glucose monitoring device by graphene modified electrochemical sensor in microfluidic system

“…4 The schematic diagram of the working process for the microfluidic chip is shown in Figure 1(b). This chip consisted of a Venturi tube 13 to provide a driving force for both ISF extraction and fluid manipulation, pneumatic valves to sequentially control the ISF extraction and collection processes, fluid chambers for the storage of the extracted and collected ISF, and interconnecting microchannels. In addition, a volume sensor was integrated into this ISF extraction microfluidic chip to monitor the input volumes of the phosphate buffer and associated diluted ISF.…”

Review of Venturi Injector Application Technology for Efficient Fertigation in Irrigation System

“…Hence the pressure difference at this point is the most important factor in this section (Wang, 2006;Sun, 2010). The divergent angle in this section is the among of the important parameter for it's greatest influence on the suction pressure which shows that according to the fluid flow condition the pressure drops in venturi injector occur s before constriction section or divergence part (Perdigones et al, 2010;Yu et al, 2012;Cheri et al, 2014;).…”

Inkjet-printed microelectrodes on PDMS as biosensors for functionalized microfluidic systems

“…PDMS-based microfluidic systems have been used extensively in the control and manipulation of different liquids [1][2][3][4][5][6] because of their remarkable biocompatibility and easy fabrication. Electrochemical detection in microfluidics is on the rise, especially in cases where the analyte is present in a sufficiently high concentration to generate a relatively high voltage or current signal, thus allowing a comparatively simple and robust read-out.…”